Identifier |
wh_ch62_p3556_3 |
Title |
Walsh & Hoyt: Pathology |
Creator |
Jacqueline Winterkorn, MD, PhD (1947-2015); Rochelle S. Zak, MD |
Affiliation |
(JW) Clinical Professor, Department of Ophthalmlogy, Weill Cornell Medicine; (RSZ) UCSF Medical Center |
Subject |
Encephalitis Lethargica; Pathology |
Description |
The neuropathologic findings in acute EL include inflammation, vasculopathy, and necrosis, consistent with viral infection. The leptomeninges show vascular congestion, with hyperemia and petechiae. Cerebral edema is present. Microscopic features of the acute infection are diffuse perivascular cuffing with lymphocytes and plasma cells. Congestion and minute hemorrhages in gray matter result from destruction of small venules. Diffuse parenchymal inflammation is composed of lymphocytes, plasma cells, and inflammatory nodules. In addition, many specimens show focal meningeal infiltration, neuronophagia, and loss of neurons with release of neuromelanin pigment into the neuropil of the locus ceruleus, cerebellum, ocular motor nuclei, and pars compacta of the substantia nigra. Chronic cases show extensive astrogliosis, especially in frontal and temporal white matter, persistent perivascular infiltrates, and, occasionally, perivascular or intraparenchymal mineralization in the striatum, hippocampus, thalamus, and brainstem. |
Date |
2005 |
Language |
eng |
Format |
application/pdf |
Type |
Text |
Source |
Walsh and Hoyt's Clinical Neuro-Ophthalmology, 6th Edition |
Relation is Part of |
Walsh and Hoyt's Clinical Neuro-Ophthalmology Walsh and Hoyt's Clinical Neuro-Ophthalmology |
Collection |
Neuro-Ophthalmology Virtual Education Library: Walsh and Hoyt Textbook Selections Collection: https://NOVEL.utah.edu |
Publisher |
Wolters Kluwer Health, Philadelphia |
Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
Rights Management |
Copyright 2005. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
ARK |
ark:/87278/s6zs650g |
Setname |
ehsl_novel_whts |
ID |
186665 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6zs650g |