Identifier |
wh_ch19_p940_1 |
Title |
Walsh & Hoyt: Huntington's Disease |
Creator |
David S. Zee, MD; David Newman-Toker, MD, PhD |
Affiliation |
(DSZ) Professor of Neurology, Johns Hopkins University; (DN) Associate Professor, Departments of Neurology, Ophthalmology, & Otolaryngology, The Johns Hopkins University School of Medicine |
Subject |
Ocular Motor System; Ocular Motility Disorders; Huntington's Disease |
Description |
Huntingtons disease produces disturbances of voluntary gaze, particularly saccades. It is caused by a genetic defect of the IT15 gene (the ""Huntington"" gene) on chromosome 4, producing a CAG triplet repeat. Initiation of saccades in patients with Huntingtons disease may be difficult. Such patients show prolonged latencies, especially when the saccade is to be made on command, in anticipation of a target moving in a predictable fashion, or in a self-paced fashion. An obligatory blink or head turn may be used to start the eye moving. Saccades may be slow in the horizontal or vertical plane; this deficit can often be detected early in the disease if eye movements are measured, but it may not be evident clinically until late in the course. Saccades may be slower in patients who become symptomatic at an earlier age, and such persons are more likely to have inherited the disease from their father. The slowing of vertical saccades in Huntingtons disease probably does not occur in patients with chorea from nondegenerative conditions or tardive dyskinesia. Longitudinal studies of saccades can be used to quantify the progression of the disease. |
Date |
2005 |
Language |
eng |
Format |
application/pdf |
Type |
Text |
Source |
Walsh and Hoyt's Clinical Neuro-Ophthalmology, 6th Edition |
Relation is Part of |
Walsh and Hoyt's Clinical Neuro-Ophthalmology Walsh and Hoyt's Clinical Neuro-Ophthalmology |
Collection |
Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
Publisher |
Wolters Kluwer Health, Philadelphia |
Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah, 10 N 1900 E SLC, UT 84112-5890 |
Rights Management |
Copyright 2005. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
ARK |
ark:/87278/s6ck1nx4 |
Setname |
ehsl_novel_whts |
ID |
185973 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6ck1nx4 |