A New Form of Glutamate Signaling Discovered in Migraine

Update item information
Identifier new_form_glutamate_signaling
Title A New Form of Glutamate Signaling Discovered in Migraine
Creator Brennan, K.C. U of U Health Key Faculty Collaborators: Sawant-Pokam, P.; Kaufmann, D.; Neurology; School of Medicine; University of Utah Health
Subject Diffusion of Innovation; Migraine Disorders; Receptors, Neurotransmitter; Glutamates; Receptors, Glutamate; Migraine with Aura; Nervous System Diseases; Microscopy; Astrocytes; Signal Transduction; Knowledge Discovery
Keyword Neuroscience
Image Caption A) Plumes result from an imbalance between release of glutamate from neurons and its reuptake by astrocytes. B) Plumes occur both during initiation (left) and propagation (right) of spreading depolarizations (SD), waves of excitation that occur in multiple neurologic diseases.
Description Migraine is a disorder of the sensory nervous system, consisting of head pain and debilitating sensory amplifications, wherein the normal senses we use in daily living become painful. Although migraine is thought to be the result of increased nervous system excitability, the actual mechanisms are poorly understood. Using two-photon microscopy, K.C. Brennan, MD, and colleagues discovered unusual activity of the excitatory neurotransmitter glutamate in mice carrying a mutated gene identified from a family with inherited migraine. These ‘plumes' of glutamate release were much more common in mice carrying the migraine mutation than in those without. Moreover, a flurry of plume events preceded spreading depolarizations, massive waves of excitation that cause the migraine aura. This novel finding is important beyond migraine, because spreading depolarizations occur in several other conditions, including stroke and traumatic brain injury. Thus, plumes represent a novel mechanism of excitability in the brain, relevant to a broad array of neurologic diseases.
Relation is Part of 2021
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date Digital 2021
Date 2021
Type Image
Format application/pdf
Rights Management Copyright © 2021, University of Utah, All Rights Reserved
Language eng
ARK ark:/87278/s6xq34wk
References 1.) Non-canonical glutamate signaling in a genetic model of migraine with aura. Parker PD, Suryavanshi PS, Melone M, Sawant-Pokam PM, Reinhart KM, Kaufmann D, Theriot JJ, Pugliese A, Conti F, Shuttleworth CW, Pietrobon D, Brennan KC. Neuron.2021 Feb 17;109(4):611.e8. PMID: 33321071.
Press Releases and Media University of Utah Health: "Unexpected Study Leads to Better Understanding of Migraine" https://healthcare.utah.edu/publicaffairs/news/2020/12/migraine-aura.php; Naked Scientists Podcast https://www.thenakedscientists.com/articles/interviews/potential-origin-migraines; Bioworld https://www.bioworld.com/articles/501456-glutamate-plumes-identified-in-spreading-depression-migraine; KUTV https://kutv.com/news/local/unexpected-discovery-leads-to-better-understanding-of-migraine; Deutschlandfunkkultur https://www.deutschlandfunkkultur.de/migraene-der-feind-in-meinem-kopf.976.de.html?dram:article_id=492379; Technology Networks https://www.technologynetworks.com/neuroscience/news/neurotransmitter-plumes-could-explain-migraine-343982; Biocompare https://www.biocompare.com/Life-Science-News/571135-Glutamate-Plumes-Could-Trigger-Migraine-with-Aura/; Neuroscience News https://neurosciencenews.com/glutamate-migraine-17435/; Science Alert https://www.sciencealert.com/glutamate-tsunamis-in-the-brain-have-been-linked-to-migraine-aura; Neuroscience News and Research https://www.facebook.com/NeuroNewsResearch/posts/3991901710828557; NewsLanded https://newslanded.com/2020/12/15/a-tsunami-like-mechanism-in-mice-brains-teach-us-more-about-migraines/; MedIndia https://www.medindia.net/news/migraine-pathology-finally-deciphered-by-glutamate-198884-1.htm; X-MOL https://www.x-mol.com/paper/1338636497164492800; RT https://www.rt.com/news/509750-tsunami-mechanism-brain-migraine/
Setname ehsl_50disc
ID 1703474
Reference URL https://collections.lib.utah.edu/ark:/87278/s6xq34wk