Genetics of Alcohol Abuse -from Flies to Humans

Update item information
Identifier genetics-alcohol-abuse
Title Genetics of Alcohol Abuse -from Flies to Humans
Creator Rothenfluh, A. U of U Health Key Faculty Collaborators: Rodan, A.; Kadrmas, J.; Beckerle, M.; Department of Psychiatry; School of Medicine; University of Utah Health
Keyword Health and Disease
Image Caption In the fly liquid-food interaction counter assay, flies choose between liquid sugar with (left) or without (right) 15% alcohol, yielding a measure for flies' alcohol preference.
Description Genetic factors play a major role in the development of human alcohol use disorder. The fruit fly, Drosophila melanogaster, has been used as a model organism to isolate and characterize genes in many physiological disorders. Like many humans, flies initially dislike alcohol, but develop a taste for it with continued experience. In an unbiased screen, the lab directed by Adrian Rothenfluh, PhD, isolated flies lacking a certain gene (Rsu1) that produces a strong liking for alcohol, even before repeated exposure. Their investigations in Drosophila showed that Rsu1 and downstream signaling molecules regulate actin dynamics; genetic manipulations that increase actin filament turnover lead to accelerated development of alcohol preference, while manipulations that increase actin filament stability abolish the development of preference. Furthermore, they showed that variants of the human Rsu1 gene are associated with altered drinking behavior and with changes in brain activity after receiving a reward. Together, these findings show the power of unbiased approaches in model organisms to generate insights that can be translated to humans to advance scientific understanding of the genetic mechanisms driving alcohol use disorder.
Relation is Part of 2015
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date Digital 2021
Date 2015
Type Image
Format image/jpeg
Rights Management Copyright © 2021, University of Utah, All Rights Reserved
Language eng
ARK ark:/87278/s62g3ndb
References 1.) Rsu1 regulates ethanol consumption in drosophila and humans. Ojelade SA, Jia T, Rodan AR, Chenyang T, Kadrmas JL, Cattrell A, Ruggeri B, Charoen P, Lemaitre H, Banaschewski T, Büchel C, Bokde ALW, Carvalho F, Conrod F, Flor H, Frouin V, Gallinat J, Garavan H, Gowland PA, Heinz A, Ittermann B, Lathrop M, Lubbe S, Martinot JL, Paus T, Smolka MN, Spanagel R, O'Reilly PF, Laitinen J, Veijola JM, Feng J, Desrivières S, Jarvelin MR, Schumann G, Rothenfluh A. Proc. Natl. Acad. Sci. U.S.A. 2015 Jul;112(30):E4085. 2.) Altered actin filament dynamics in the drosophila mushroom bodies lead to fast acquisition of alcohol consumption preference. Butts AR, Ojelade SA, Pronovost ED, Seguin A, Merrill CB, Rodan AR, Rothenfluh A. J Neurosci. 2019 Nov 6;39(45):8877.
Press Releases and Media Irish Times https://www.irishtimes.com/news/science/fruit-fly-helps-scientists-identify-gene-linked-to-humans-alcohol-consumption-1.2283847; PNAS https://www.pnas.org/content/112/47/E6411.short
Setname ehsl_50disc
Date Created 2021-06-22
Date Modified 2021-06-24
ID 1703473
Reference URL https://collections.lib.utah.edu/ark:/87278/s62g3ndb
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