Determinants of Fat Tissue Expansion

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Identifier determinants_of_fat_tissue_expansion
Title Determinants of Fat Tissue Expansion
Creator Boudina, S.; Nutrition & Integrative Physiology; College of Health; University of Utah Health
Subject Diffusion of Innovation; Abdominal Fat; Intra-Abdominal Fat; Adiposity; Adipogenesis; Adipose Tissue; Adipocytes; Metabolic Diseases; Metabolic Syndrome; Hypertrophy; Knowledge Discovery
Keyword Diabetes and Metabolism
Image Caption Unanticipated heterogeneity in the cell populations that comprise adipose depots.
Description Adipose tissue (fat) is a complicated organ that can undergo massive expansion in response to nutritional overload. The Boudina lab discovered adipose progenitors with potent anti-adipogenic potential. These cells, which are unique to visceral fat and found in both humans and mice, could explain the propensity of visceral fat to grow by hypertrophy in response to caloric excess. They also identified a set of regulatory events that control healthy adipose expansion. This finding of heterogeneity in the adipose tissue reveals potential opportunities for therapeutic intervention to enable healthy adipose expansion and combat cardiometabolic disease.
Relation is Part of 2019
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date Digital 2020
Date 2019
Type Image
Format image/jpeg
Rights Management Copyright © 2021, University of Utah, All Rights Reserved
Language eng
ARK ark:/87278/s69656pq
References 1.) Identification of a paracrine signaling mechanism linking CD34High progenitors to the regulation of visceral fat expansion and remodeling. Buffolo M, Pires KM, Ferhat M, Ilkun O, Makaju A, Achenbach A, Bowman F, Atkinson DL, Holland WL, Amri EZ, Chaurasia B, Franklin S, Boudina S. Cell Rep. 2019 Oct;29(2):270.
Setname ehsl_50disc
ID 1589399
Reference URL