Host-Microbe Battles over Iron

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Title Host-Microbe Battles over Iron
Creator Elde, N.C.
Subject Diffusion of Innovation; Communicable Diseases; Transferrin; Transferrin-Binding Proteins; Host-Pathogen Interactions; Haemophilus influenzae; Gallionellaceae; Iron; Iron, Dietary; Biological Evolution; Mutation; Bacteria; Genetic Variation; Knowledge Discovery
Keyword Immunology, Inflammation, Infectious Disease
Image Caption Left: Traces of the ancient battle for iron are in the DNA of people worldwide (green). Right: Mutations over evolutionary time have enabled pathogens to scavenge iron by binding the host transferrin protein, and for the host to evade this iron piracy. (Janet Iwasa).
Description Hosts and pathogens are locked in an endless battle to gain selective advantages over one another. Host-pathogen interactions therefore provide valuable systems for studying evolutionary genetics, natural selection, microbiology and infectious disease. The sequestration of essential iron has emerged as a crucial innate defense system termed nutritional immunity, leading pathogens to evolve mechanisms of 'iron piracy' to scavenge this essential metal from host proteins. This battle for iron carries numerous consequences not only for host-pathogen evolution but also microbial community interactions. The Elde lab demonstrated that the iron carrier protein transferrin has evolved to allow hosts to escape bacterial "iron piracy". For example, one transferrin polymorphism allows hosts to evade iron piracy by the pathogenic bacterium, Haemophilus influenzae, revealing a functional basis for standing genetic variation in the human population. These findings identify a central role for nutritional immunity in the persistent evolutionary conflicts between primates and bacterial pathogens.
Relation is Part of 2019
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date Digital 2020
Date 2015
Type Image
Format image/jpeg
Rights Management Copyright © 2021, University of Utah, All Rights Reserved
Language eng
ARK ark:/87278/s6t786hm
References 1.) Escape from bacterial iron piracy through rapid evolution of transferrin. Barber MF, Elde NC. Science. 2014 Dec;346(6215):1362-6. 2.) Buried treasure: evolutionary perspectives on microbial iron piracy. Barber MF, Elde NC. Trends Genet. 2015 Nov;31(11):627-636.
Press Releases and Media Human DNA Shows Traces of 40 Million-Year Battle for Survival Between Primate and Pathogen; New York Times; National Geographic
Setname ehsl_50disc
ID 1589395
Reference URL
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