Lipid Metabolism and Cardiometabolic Disease
| Title | Lipid Metabolism and Cardiometabolic Disease |
| Creator | Summers, S.A. |
| Subject | Diffusion of Innovation; Lipid Metabolism; Metabolic Syndrome; Ceramides; Sphingolipids; Adipose Tissue; Fatty Liver; Non-alcoholic Fatty Liver Disease; Diabetes Mellitus; Glucose; Insulin Resistance; Cardiovascular Diseases; Coronary Artery Disease; Heart Disease Risk Factors; Biomarkers; Apoptosis; Homeostasis; Drug Discovery; Knowledge Discovery |
| Keyword | Diabetes and Metabolism |
| Image Caption | Ceramides are signals of lipid excess that inhibit glucose utilization and induce lipid accumulation and hepatocyte apoptosis - all key features of the Metabolic Syndrome. |
| Description | Metabolic diseases such as diabetes, steatohepatitis, and coronary artery disease result from the delivery of nutrients that exceed a tissue's energetic needs or storage capacity. The excess nutrients give rise to deleterious lipid species that impair cellular function. Summers and colleagues found that ceramides, a class of sphingolipids, alter metabolism of liver and adipose tissue in a way that gives rise to cardiometabolic disease. They also discovered that removing a single double-bond from ceramides is sufficient to restore metabolic homeostasis in diseased rodents. Lastly, they discovered that circulating ceramides were potent biomarkers of coronary artery disease. These data have inspired drug discovery efforts to lower ceramides and improve cardiometabolic health. |
| Relation is Part of | 2019 |
| Publisher | Spencer S. Eccles Health Sciences Library, University of Utah |
| Date Digital | 2020 |
| Date | 2019 |
| Type | Image |
| Format | image/jpeg |
| Rights Management | Copyright © 2021, University of Utah, All Rights Reserved |
| Language | eng |
| ARK | ark:/87278/s66f1h47 |
| References | 1.) Targeting a ceramide double bond improves insulin resistance and hepatic steatosis. Chaurasia B, Tippetts TS, Mayoral Monibas R, Liu J, Li Y, Wang L, Wilkerson JL, Sweeney CR, Pereira RF, Sumida DH, Maschek JA, Cox JE, Kaddai V, Lancaster GI, Siddique MM, Poss A, Pearson M, Satapati S, Zhou H, McLaren DG, Previs SF, Chen Y, Qian Y, Petrov A, Wu M, Shen X, Yao J, Nunes CN, Howard AD, Wang L, Erion MD, Rutter J, Holland WL, Kelley DE, Summers SA. Science. 2019 Jul;365(6451):386. https://pubmed.ncbi.nlm.nih.gov/31273070/ 2.) Metabolic messengers: Ceramides. Summers SA, Chaurasia B, Holland WL Nature Metabolism. 2019 Oct:1051. https://www.nature.com/articles/s42255-019-0134-8 3.) Machine learning reveals serum sphingolipids as cholesterol-independent biomarkers of coronary artery disease. Poss AM, Maschek JA, Cox JE, Hauner BJ, Hopkins PN, Hunt SC, Holland WL, Summers SA, Playdon MC. J Clin Invest. 2019 Nov. pii: 131838. https://pubmed.ncbi.nlm.nih.gov/31743112/. See also: Tiny Change Has Big Effects, Reverses Prediabetes in Mice (https://healthcare.utah.edu/publicaffairs/news/2019/07/reverse-prediabetes.php); People with High Ceramide Levels Up to Four Times More Likely to Have Heart Attacks, Stroke (https://uofuhealth.utah.edu/newsroom/news/2019/12/-ceramides-summers.php) |
| Press Releases and Media | Science Daily https://www.sciencedaily.com/releases/2019/07/190704191347.htm; Fierce Biotech https://www.fiercebiotech.com/research/subtle-chemical-shift-reverses-prediabetes-merck-partnered-mouse-trial; Nutrition Insight https://www.nutritioninsight.com/news/gene-editing-can-reverse-prediabetes-in-mice-and-potentially-humans-study-reveals.html; KSL https://www.ksl.com/article/46588771/u-researchers-make-tiny-change-in-metabolism-of-mice-successfully-reverse-prediabetes; Genetic Engineering and Biotechnology News https://www.genengnews.com/news/potential-diabetes-target-makes-subtle-chanages-with-big-impact-on-metabolic-health/; Science Codex https://www.sciencecodex.com/tiny-change-has-big-effects-reverses-prediabetes-mice-628928; Science Blog https://scienceblog.com/508772/tiny-change-has-big-effects-reverses-prediabetes-in-mice/; Health Medicine Network http://healthmedicinet.com/i/tiny-change-has-big-effects-reverses-prediabetes-in-mice/; Science Daily https://www.sciencedaily.com/releases/2019/07/190704191347.htm; MyHealthyClick. |
| Setname | ehsl_50disc |
| ID | 1589392 |
| Reference URL | https://collections.lib.utah.edu/ark:/87278/s66f1h47 |