Designing Proteins to Carry Cargoes Between Cells

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Identifier designing_proteins_to_carry_cargoes_between_cells
Title Designing Proteins to Carry Cargoes Between Cells
Creator Sundquist, W.I.; Biochemistry; School of Medicine; University of Utah Health
Subject Diffusion of Innovation; Nanostructures; Bioengineering; Biomimetics; Viruses; Biological Phenomena; Systems Biology; Computational Biology; Ribosomes; Ribosomal Proteins; Amino Acid Sequence; Proteins; Protein Conformation; Genetic Therapy; Knowledge Discovery
Keyword Drug Discovery
Image Caption Designed protein nanocages released within membrane vesicles.
Description Complex biological processes are often performed by self-organizing nanostructures comprising multiple classes of macromolecules, such as ribosomes (proteins and RNA) or enveloped viruses (proteins, nucleic acids and lipids). Approaches have been developed for designing synthetic self-assembling structures consisting of either nucleic acids or proteins, but strategies for engineering hybrid biological materials are only beginning to emerge. Sundquist, King, Belnap and colleagues reported the de novo design and characterization of proteins that direct their own assembly and release from human cells within membrane vesicles. These virus-inspired delivery systems can also transfer biological cargoes between cells, and therefore represent an important first step in the development of new synthetic systems for delivering therapeutic cargoes into diseased target cells.
Relation is Part of 2016
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date Digital 2020
Date 2016
Type Image
Format image/jpeg
Rights Management Copyright © 2021, University of Utah, All Rights Reserved
Language eng
ARK ark:/87278/s6fz30jh
References 1.) Designed proteins induce the formation of nanocage-containing extracellular vesicles. Votteler J, Ogohara C, Yi S, Hsia Y, Nattermann U, Belnap DM, King NP, Sundquist WI. Nature. 2016 Dec;540(7632):292-295.
Press Releases and Media Virus-Inspired Delivery System Transfers Microscopic Cargo Between Human Cells; PhysicsOrg; ScienceDaily
Setname ehsl_50disc
Date Created 2020-08-13
Date Modified 2021-05-06
ID 1589390
Reference URL
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