Architecture of the Inner Ear

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Identifier architecture_of_the_inner_ear
Title Architecture of the Inner Ear
Creator Park, S.; Internal Medicine/Surgery; School of Medicine; University of Utah Health
Subject Diffusion of Innovation; Ear, Inner; Tectorial Membrane; Anatomy, Morphogenesis; Extracellular Matrix; Cross-Sectional; Printing, Three-Dimensional; Knowledge Discovery
Keyword Neuroscience
Image Caption 3D printing model for complex extracellular matrix. (A) PSA-lectin staining of the developing cochlea shows the complex matrix architecture of the tectorial membrane of the inner ear. (B) 3D printing model: printing of a new layer and simultaneous release of pre-established layer to build a multi-layered structure.
Description Normal hearing is dependent upon a highly specialized structure in the inner ear called the tectorial membrane. How this precisely organized extracellular matrix is assembled had been unknown. However, Park and colleagues showed the inner ear membrane anchors to the cell surface during development and grows one layer at a time. This process depends upon anchoring and then release of the GPI-anchored protein TECTA. Once a layer is formed, TECTA is released, and the next layer is ‘printed' underneath it. The mechanism is similar to 3D printing and eventually results in a multi-layered architecture. This proposed 3D printing model provides novel insight into our understanding of the extracellular matrix morphogenesis process during development and tissue repair.
Relation is Part of 2019
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date Digital 2020
Date 2019
Type Image
Format image/jpeg
Rights Management Copyright © 2021, University of Utah, All Rights Reserved
Language eng
ARK ark:/87278/s6mq0s9w
References 1.) The release of surface-anchored α-tectorin, an apical extracellular matrix protein, mediates tectorial membrane organization. Kim DK, Kim JA, Park J, Niazi A, Almishaal A, Park S. Sci Adv. 2019 Nov;5(11):eaay6300.
Press Releases and Media Nature Middle East
Setname ehsl_50disc
ID 1589381
Reference URL