Gene Expression and Health Risks

Update item information
Identifier gene_expression_and_health_risks
Title Gene Expression and Health Risks
Creator Gregg, C.; Neurobiology & Anatomy; School of Medicine; University of Utah Health
Subject Diffusion of Innovation; Aging; Disease Resistance; Risk Factors; Genetic Predisposition to Disease; Gene Expression Regulation; Phenotype; Genotype; Genetic Predisposition to Disease; Genome; Databases, Genetic; Promoter Regions, Genetic; Transcription Factors; Regulatory Sequences, Nucleic Acid; Knowledge Discovery
Keyword Genomics
Image Caption An analysis of accelerated evolution in species with highly distinctive traits reveals candidate functional genomic elements for shaping somatic mutation rate, cancer risk, digit development, immunity, glaucoma, pigmentation, and other clinical phenotypes.
Description An important area of research involves learning how the expression of our genes influences health and disease risks. The parts of the genome that regulate gene expression are cis-regulatory elements. Gregg and colleagues took an unusual approach to discover these cis-regulatory elements by analyzing the genomes of species that evolved disease resistance "superpowers". For example, elephants have large bodies with many cells and have evolved unique mechanisms to prevent cancer. By comparing the elephant genome to smaller, less cancer-resistant species, they uncovered putative master cis-regulatory elements in the genome that shape mammalian cancer resistance. In a separate study, they studied hibernating mammals that have evolved unique controls over metabolism, obesity and aging. By comparing their genomes to non-hibernating species, they found cis-regulatory elements that are putative master regulators of mammalian obesity, feeding, metabolism and aging. In total, the Gregg lab has analyzed the genomes of over ten species with different biomedical superpowers, creating an atlas of cis-regulatory elements linked to clinically important phenotypes.
Relation is Part of 50 Basic Science Discoveries in 5 Years- 2019
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date Digital 2020
Date 2019
Type Image
Format image/jpeg
Rights Management Copyright © 2020, University of Utah, All Rights Reserved
Language eng
ARK ark:/87278/s61w142q
References 1.) Accelerated evolution in distinctive species reveals eandidate elements for clinically relevant traits, including mutation and cancer resistance. Ferris E, Abegglen LM, Schiffman JD, Gregg C. Cell Rep. 2018 Mar;22(10):2742-2755. https://pubmed.ncbi.nlm.nih.gov/29514101/ 2.) Parallel accelerated evolution in distant hibernators reveals candidate cis elements and genetic circuits regulating mammalian obesity. Ferris E, Gregg C. Cell Rep. 2019 Nov;29(9):2608-2620. https://pubmed.ncbi.nlm.nih.gov/31775032/
Press Releases and Media Hibernating Mammals Arouse Hope for Genetic Solutions to Obesity, Metabolic Diseases https://healthcare.utah.edu/publicaffairs/news/2019/11/hibernation-obesity.php; Mapping the Genome Jungle: Unique Animal Traits Could Offer Insight into Human Disease https://healthcare.utah.edu/publicaffairs/news/2018/03/animal-genome.php; NBC News https://www.nbcnews.com/health/health-care/why-don-t-elephants-get-cancer-new-gene-study-explains-n854321; Newsweek https://www.newsweek.com/scientists-reveal-why-elephants-dont-get-cancer-and-what-means-treating-human-834234; Genome Web https://www.genomeweb.com/sequencing/cross-species-genome-comparison-uncovers-regulatory-elements-ties-clinical-phenotypes#.X2FCPTFKhyw; Daily Mail https://www.dailymail.co.uk/health/article-7727499/Could-hibernation-treat-obesity-Obese-people-share-similar-genes-hibernating-animals.html; International Business Times https://www.ibtimes.com/scientists-look-hibernating-bears-dna-help-treat-obesity-2874402; STAT top biomedical breakthrough of 2018.
Setname ehsl_50disc
Date Created 2020-08-13
Date Modified 2020-11-17
ID 1589370
Reference URL https://collections.lib.utah.edu/ark:/87278/s61w142q