Fast-acting Insulins from Cone Snails

Update item information
Identifier fast-acting_insulins_from_cone_snails
Title Fast-acting Insulins from Cone Snails
Creator Safavi-Hemami, H., Chou, D.; Biochemistry; School of Medicine; University of Utah Health
Subject Diffusion of Innovation; Conus Snail; Insulin, Regular, Human; Insulins; Insulin Infusion Systems; Receptor, Insulin; Hypoglycemia; INSR protein, human; Diabetes Mellitus; Models, Animal; Knowledge Discovery
Keyword Diabetes and Metabolism
Image Caption Model showing how mini-insulin (mini-Ins, gold and green) binds human insulin receptor (hIR, powder blue, magenta and tan) and replaces key interactions made by the terminal segment of human insulin (h-Ins, black).
Description Faster acting human insulins are needed to improve the efficacy of diabetic insulin pumps. Over the past few years, collaborating teams led by Olivera, Safavi-Hemami, Schlegel, Yandell, and Chou have made the remarkable discovery that fish-hunting cone snails use fast-acting insulins to inactivate their prey by inducing hypoglycemia. The team characterized these toxins and used the information gained to design a new fast-acting, stable human mini-insulin analog that has more rapid onset than current competitors in porcine diabetes models.
Relation is Part of 50 Basic Science Discoveries in 5 Years- 2019
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date Digital 2020
Date 2019
Type Image
Format image/jpeg
Rights Management Copyright © 2020, University of Utah, All Rights Reserved
Language eng
ARK ark:/87278/s6jx441d
References 1.) Specialized insulin is used for chemical warfare by fish-hunting cone snails. Safavi-Hemami H, Gajewiak J, Karanth S, Robinson SD, Ueberheide B, Douglass AD, Schlegel A, Imperial JS, Watkins M, Bandyopadhyay PK, Yandell M, Li Q, Purcell AW, Norton RS, Ellgaard L, Olivera BM. Proceedings of the National Academy of Sciences USA. 2015 Feb;112(6):1743. 2.) Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor. Ahorukomeye P, Disotuar MM, Gajewiak J, Karanth S, Watkins M, Robinson SD, Flórez Salcedo P, Smith NA, Smith BJ, Schlegel A, Forbes BE, Olivera B, Hung-Chieh Chou D, Safavi-Hemami H. Elife. 2019 Feb;8. pii:e41574.
Press Releases and Media Gory, Freaky, Cool: Marina Snail Venom Could Improve Insulin for Diabetic Patients; Elife Article Highlight; Elife Podcast Highlight; ABC4; Science Daily; Popular Science; New Atlas; International Business Times
Setname ehsl_50disc
Date Created 2020-08-13
Date Modified 2020-11-17
ID 1589366
Reference URL