Drug Discovery in Exotic Marine Symbionts

Update item information
Identifier drug_discovery_in_exotic_marine_symbionts
Title Drug Discovery in Exotic Marine Symbionts
Creator Haygood, M.G.; Medicinal Chemistry; College of Pharmacy; University of Utah Health
Subject Diffusion of Innovation; Drug Discovery; Bivalvia; Bacteria; Polysaccharides, Bacterial; Bacteroides fragilis; Microbiota; Symbiosis; Gastrointestinal Microbiome; Anatomy, Comparative; Hot Temperature; Knowledge Discovery
Keyword Drug Discovery
Image Caption Comparative anatomy and life position of two different species of giant shipworms.
Description Rare and exotic marine organisms have proven to be a promising source of new drugs and other bioactive compounds. Haygood and collaborators have discovered that giant shipworms and other mollusks harbor a rich ecosystem of symbiotic bacteria, and that the symbiotic relationships between marine bacteria and marine animals are based on chemical signals exchanged between mollusks, for instance, and their bacterial symbionts. The discoveries garnered significant attention owing to their potential for providing rich platforms for drug discovery. The "wooden-steps" hypothesis proposed that large chemosynthetic mussels found at deep-sea hydrothermal vents descend from much smaller species associated with sunken wood and other organic deposits and that the endosymbionts of these progenitors made use of hydrogen sulfide from biogenic sources (e.g., decaying wood) rather than from vent fluids. The study of bacterial symbiosis in exotic organisms, such as shipworm mollusks, illustrates universal principles that may be applied to the human microbiome.
Relation is Part of 50 Basic Science Discoveries in 5 Years- 2019
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date Digital 2020
Date 2019
Type Image
Format image/jpeg
Rights Management Copyright © 2020, University of Utah, All Rights Reserved
Language eng
ARK ark:/87278/s6z37nrm
References 1.) Discovery of chemoautotrophic symbiosis in the giant shipworm Kuphus polythalamia (Bivalvia: Teredinidae) extends wooden-steps theory. Distel DL, Altamia MA, Lin Z, Shipway JR, Han A, Forteza I, Antemano R, Limbaco MGJP, Tebo AG, Dechavez R, Albano J, Rosenberg G, Concepcion GP, Schmidt EW, Haygood MG. Proc Natl Acad Sci US A. 2017 May;114(18):E3652. https://pubmed.ncbi.nlm.nih.gov/28416684/ 2.) Mindapyrroles A-C, pyoluteorin analogues from a shipworm-associated bacterium. Lacerna NM 2nd, Miller BW, Lim AL, Tun JO, Robes JMD, Cleofas MJB, Lin Z, Salvador-Reyes LA, Haygood MG, Schmidt EW, Concepcion GP. J Nat Prod. 2019 Apr;82(4):1024. https://pubmed.ncbi.nlm.nih.gov/30793902/
Press Releases and Media Science Fiction Horror Wriggles into Reality with Discovery of Giant Sulfur-Powered Shipworm https://healthcare.utah.edu/publicaffairs/news/2017/04/shipworm.php; Jeopardy https://www.youtube.com/watch?v=yYc0ZTRZKEI&feature=youtu.be; New York Times https://www.nytimes.com/2017/04/18/science/giant-shipworm.html?_r=0; Washington Post https://www.washingtonpost.com/news/speaking-of-science/wp/2017/04/17/scientists-find-giant-elusive-clam-known-as-the-unicorn-of-mollusks/; CBS News https://www.cbsnews.com/news/an-ocean-unicorn-3-foot-marine-worm-seen-for-the-first-time/; Smithsonian https://www.smithsonianmag.com/smart-news/giant-shipworm-finally-found-after-180962944/#AkRP5t16chTWqlZt.99; National Geographic https://www-staging.nationalgeographic.com/news/2017/04/shipworm-giant-oceans-rare-bacteria/; Wired https://www.wired.com/2017/04/mystery-5-foot-long-shipworm-just-got-stinkier/; Popular Science https://www.popsci.com/legendary-shipworm-species/; Newsweek https://www.newsweek.com/shipworm-feeds-gas-found-philippines-lagoon-585307; BBC https://www.bbc.com/news/world-asia-39626131; The Telegraph https://www.telegraph.co.uk/news/2017/04/18/scientists-extract-rare-giant-shipworm-toe-curling-video/; The Australian; KSL https://www.ksl.com/article/43922085; Fox 13 https://www.fox13now.com/2017/04/17/u-of-u-researchers-discover-giant-shipworm/.
Setname ehsl_50disc
Date Created 2020-08-13
Date Modified 2020-11-17
ID 1589363
Reference URL https://collections.lib.utah.edu/ark:/87278/s6z37nrm