Developing New Chemical Reactions that Can Be Performed in Living Cells

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Identifier developing_new_chemical_reactions_that_can_be_performed_in_living_cells
Title Developing New Chemical Reactions that Can Be Performed in Living Cells
Creator Franzini, R.M.; Medicinal Chemistry; College of Pharmacy; University of Utah Health
Subject Diffusion of Innovation; Biomedical Research; Click Chemistry; Chemistry Techniques, Synthetic; Combinatorial Chemistry Techniques; Cycloaddition Reaction; Indicators and Reagents; Knowledge Discovery
Keyword Drug Discovery
Image Caption Dissociative biorthogonal reactions allow for chemical control of the release of bioactive agents and reporter probes.
Description The development of bioorthogonal chemical reactions-chemical reactions that can be conducted in living cells-has been one of the most significant areas of advancement in chemistry in recent years. Bioorthogonal reactions that join molecules together, such as "click chemistry," have created a revolution in biomedical research. However, there are fewer bioorthogonal reactions that can split molecules. Franzini and colleagues have developed a series of highly efficient chemical reactions, termed "dissociative bioorthogonal reactions", that do just that. These new reactions hold promise for enabling new targeted therapies and highly-sensitive diagnostic tools.
Relation is Part of 2019
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date Digital 2020
Date 2019
Type Image
Format image/jpeg
Rights Management Copyright © 2021, University of Utah, All Rights Reserved
Language eng
ARK ark:/87278/s66m8wvk
References 1.) Bioorthogonal removal of 3-isocyanopropyl groups enables the controlled release of fluorophores and drugs in vivo. Tu J, Xu M, Parvez S, Peterson RT, Franzini RM. J Am Chem Soc. 2018 Jul;140(27):8410. https://pubmed.ncbi.nlm.nih.gov/29927585/ 2.) Stable, reactive, and orthogonal tetrazines: dispersion forces promote the cycloaddition with isonitriles. Tu J, Svatunek D, Parvez S, Liu AC, Levandowski BJ, Eckvahl HJ, Peterson RT, Houk KN, Franzini RM. Angew Chem Int Ed Engl. 2019 Jul;58(27):9043. https://pubmed.ncbi.nlm.nih.gov/31062496/
Setname ehsl_50disc
Date Created 2020-08-13
Date Modified 2021-05-06
ID 1589361
Reference URL https://collections.lib.utah.edu/ark:/87278/s66m8wvk
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