Causes of Type 1 Diabetes

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Title Causes of Type 1 Diabetes
Creator Bettini, M.; Bettini, M.L.; Evavold, B.
Subject Diffusion of Innovation: Diabetes Mellitus, Type 1; Insulin-Secreting Cells; Insulin; Insulin, Regular, Human; Immune Tolerance; T-Lymphocytes, Regulatory; Knowledge Discovery
Keyword Diabetes and Metabolism
Image Caption Two harmless peptides are fused to activate high affinity T cells in Type 1 diabetes.
Description More than 1 million Americans suffer from Type 1 diabetes, which occurs when immune T cells attack the patient's own pancreas by mistake. Understanding why this occurs is key to developing treatments that target the cause, not just the symptoms of diabetes. Recent advances by Bettini, Evavold, Liu and colleagues have shown that specific fusions/modifications between insulin and other proteins creates new immunological targets that allow pathogenic high affinity T cells to escape tolerance, destroy pancreatic beta cells and initiate Type 1 diabetes.
Relation is Part of 2019
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date Digital 2020
Date 2019
Type Image
Format image/jpeg
Rights Management Copyright © 2021, University of Utah, All Rights Reserved
Language eng
ARK ark:/87278/s6g50dcg
References 1.) High self-reactivity drives T-bet and potentiates Treg function in tissue-specific autoimmunity. Sprouse ML, Scavuzzo MA, Blum S, Shevchenko I, Lee T, Makedonas G, Borowiak M, Bettini ML, Bettini M. JCI Insight. 2018 Jan;3(2). pii: 97322. 2.) A hybrid insulin epitope maintains high 2D affinity for diabetogenic T cells in the periphery. Liu B, Hood JD, Kolawole EM, Woodruff DM, Vignali DA, Bettini M, Evavold BD. Diabetes. 2019 Dec. pii: db190399. 3.) A critical insulin TCR contact residue selects high affinity and pathogenic insulin specific T cells. Bettini M, Scavuzzo MA, Liu B, Kolawole E, Guo L, Evavold BD, Borowiak M, Bettini ML. Diabetes. 2019 Dec. pii: db190821.
Setname ehsl_50disc
ID 1589359
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