Commensal Microbes That Help Prevent Metabolic Disease

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Identifier commensal_microbes_that_help_prevent_metabolic_disease
Title Commensal Microbes That Help Prevent Metabolic Disease
Creator Round, J.L.; Pathology; School of Medicine; University of Utah Health
Subject Diffusion of Innovation; Metabolic Diseases; Insulin Resistance; Gastrointestinal Tract; Gastrointestinal Microbiome; Symbiosis; Gastrointestinal Absorption; Immune System; Immunity; Obesity; Knowledge Discovery
Keyword Diabetes and Metabolism
Image Caption Healthy and obese animals contain different microbes in their gut.
Description Our intestines are colonized by a vast consortium of bacteria, viruses, and fungi that we now know have essential influences on gut health. Gut microbes are also instrumental for promoting the development of a mature immune system, but in turn, host immunity influences the types and functions of these commensal organisms. Research in the Round lab has recently shown that intestinal antibody responses select for specific organisms within the gut that prevent metabolic disease by limiting fat absorption within the intestine. In the absence of appropriate immunity in the gut, these protective microbes are lost, and hosts develop obesity and insulin resistance. Thus, health depends on a delicate balance between our immune system and resident gut microbes.
Relation is Part of 2019
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date Digital 2020
Date 2019
Type Image
Format image/jpeg
Rights Management Copyright © 2021, University of Utah, All Rights Reserved
Language eng
ARK ark:/87278/s6kt2fm8
References 1.) MHC variation sculpts individualized microbial communities that control susceptibility to enteric infection. Kubinak JL, Stephens WZ, Soto R, Petersen C, Chiaro T, Gogokhia L, Bell R, Ajami NJ, Petrosino JF, Morrison L, Potts WK, Jensen PE, O'Connell RM, Round JL. Nat Commun. 2015 Oct;6:8642. 2.) Causal effects of the microbiota on immune-mediated diseases. Round JL, Palm NW. Sci Immunol. 2018 Feb;3(20). pii: eaao1603. 3.) Variations in diet cause alterations in microbiota and metabolites that follow changes in disease severity in a multiple sclerosis model. Libbey JE, Sanchez JM, Doty DJ, Sim JT, Cusick MF, Cox JE, Fischer KF, Round JL, Fujinami RS. Benef Microbes. 2018 Apr;9(3):495. 4.) T cell-mediated regulation of the microbiota protects against obesity. Petersen C, Bell R, Klag KA, Lee SH, Soto R, Ghazaryan A, Buhrke K, Ekiz HA, Ost KS, Boudina S, O'Connell RM, Cox JE, Villanueva CJ, Stephens WZ, Round JL. Science. 2019 Jul;365(6451). pii: eaat9351.
Press Releases and Media These Gut Bacteria Prevent Obesity in Mice. What Could That Mean for Us?; The Atlantic; BBC; Science Daily; Health Medicine Network; Medical XPress
Setname ehsl_50disc
ID 1589358
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