Generation and Treatment of Antibiotic Resistance

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Identifier generation_and_treatment_of_antibiotic_resistance
Title Generation and Treatment of Antibiotic Resistance
Creator Mulvey, MA; Brown, J.C.S.; Pathology; School of Medicine; University of Utah Health
Subject Diffusion of Innovation; Anti-Bacterial Agents; Drug Resistance, Bacterial; Anti-Infective Agents; Anti-Bacterial Agents; Urinary Tract Infections; Treatment Outcome; Drug Repositioning; Drug Interactions; Drug Approval; Knowledge Discovery
Keyword Drug Discovery
Image Caption Bacteria can transfer genes conferring antibiotic resistance among strains infecting a single patient. To combat antibiotic resistance, researchers screened for drugs that can be repurposed to amplify the activity of existing antibiotics and inhibit resistant bacteria.
Description Antibiotics are responsible for the most significant increase in lifespan in human history. However, microbes are becoming resistant to antibiotics at an alarming rate. For example, uncontrolled drug-resistant infections can lead to recurrent urinary tract infections, sepsis, and even death. The Mulvey lab found that microbes within a single colonized site, such as the human bladder, can pass antibiotic resistance genes back and forth, propagating resistance as the infecting microbes evolve in response to serial antibiotic treatment. To improve potential treatments, the Brown lab developed methods to rapidly identify drugs that interact with existing antibiotics to increase drug efficacy. Exploiting these potentiating interactions between existing drugs allows us to expand our drug repertoire by drug repurposing - using drugs already approved by the FDA for other indications - which bypasses expensive and time-consuming clinical trials.
Relation is Part of 2019
Publisher Spencer S. Eccles Health Sciences Library, University of Utah
Date Digital 2020
Date 2019
Type Image
Format image/jpeg
Rights Management Copyright © 2021, University of Utah, All Rights Reserved
Language eng
ARK ark:/87278/s6vb3z47
References 1.) High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance. Wambaugh MA, Shakya VPS, Lewis AJ, Mulvey MA, Brown JCS. PLoS Biol. 2017 Jun;15(6):e2001644. https://pubmed.ncbi.nlm.nih.gov/28632788/ 2.) Population dynamics of an Escherichia coli ST131 lineage during recurrent urinary tract infection. Forde BM, Roberts LW, Phan MD, Peters KM, Fleming BA, Russell CW, Lenherr SM, Myers JB, Barker AP, Fisher MA, Chong TM, Yin WF, Chan KG, Schembri MA, Mulvey MA, Beatson SA. Nat Commun. 2019 Aug;10(1):3643. https://pubmed.ncbi.nlm.nih.gov/31409795/
Press Releases and Media Finding the Perfect Match: A New Approach to Battle Drug-Resistant Bacteria https://healthcare.utah.edu/publicaffairs/news/2017/06/brown-synergistic.php; Phys.org https://phys.org/news/2017-06-approach-drug-resistant-bacteria.html; Science Daily https://www.sciencedaily.com/releases/2017/06/170620143110.htm; Lab Manager Magazine https://www.labmanager.com/news/a-new-approach-to-battle-drug-resistant-bacteria-7139
Setname ehsl_50disc
Date Created 2020-08-13
Date Modified 2021-05-06
ID 1589356
Reference URL https://collections.lib.utah.edu/ark:/87278/s6vb3z47
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