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Publication Type honors thesis
School or College College of Humanities
Department English
Creator Calder, Scott Eyring
Title Zn-DTPA administered by slow-release implant
Date 1977-08
Year graduated 1977
Description Because of the short biological retention half-time of Zn-DTPA and the desirability of a maintained blood level of the chelate, alternative modes of its administration were explored. Zn-DTPA labeled with 65Zn was dried and ground to a fine powder and incorporated into implants of various combinations of cholesterol, polyethylene glycol 4000, beeswax, and peanut oil in order to produce a slow release of the chelation agent. One group of pellets, placed subcutaneously in the dorsal neck of young adult beagles, produced daily release rates of from 0.5% to 41% of the implanted DTPA, increasing with the percentage of polyethylene glycol 4000 in the pellet. When 241Am citrate was injected intravenously into beagles preimplanted with a DTPA pellet, the fraction of the injected 241Am excreted in the first 24 hours increased from 9% (control) to 38% (2.9 umole DTPA/kg/day) to 84% (70 umole/kg/day). [Supported by USERDA; Contract E (11-1)-119.]
Type Text
Publisher University of Utah
Subject Diethylenetriaminepentaacetic acid; Controlled release preparations
Language eng
Rights Management (c) Scott Eyring Calder
Format Medium application/pdf
ARK ark:/87278/s6fb91fn
Setname ir_htca
ID 1293787
Reference URL https://collections.lib.utah.edu/ark:/87278/s6fb91fn

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Title Page 21
Setname ir_htca
ID 1293808
Reference URL https://collections.lib.utah.edu/ark:/87278/s6fb91fn/1293808