Daniel R. Gold, DO, Departments of Neurology, Ophthalmology, Neurosurgery, Otolaryngology - Head & Neck Surgery, Emergency Medicine, and Medicine, The Johns Hopkins School of Medicine
This is a 40-yo-woman with anti-Yo antibody associated with ovarian cancer. Initial symptoms 2.5 years prior (to this video) included imbalance and dysarthria. She complained of oscillopsia which was due to her upbeat nystagmus (presumably the result of brainstem involvement), and diplopia (she had an esotropia greater at distance which is common with cerebellar pathology). There were also intermittent spontaneous saccadic intrusions, hypermetric saccades, choppy smooth pursuit and VOR suppression - ocular motor abnormalities that are commonly seen with posterior fossa disease. At the time when the video was taken (2.5 years after symptom onset), severe brainstem and cerebellar atrophy was apparent on MRI.
Spencer S. Eccles Health Sciences Library, University of Utah