| Publication Type |
journal article |
| School or College |
College of Science |
| Department |
Biology |
| Creator |
Olivera, Baldomero M. |
| Other Author |
Terlau, Heinrich; Boccaccio, Anna; Conti, Franco |
| Title |
Block of Shaker K+ channels by ĸ-conotoxin PVIIA is state dependent |
| Date |
1999 |
| Description |
ĸ-conotoxin PVIIA is the first conotoxin known to interact with voltage-gated potassium channels by inhibiting Shaker-mediated currents. We studied the mechanism of inhibition and concluded that PVIIA blocks the ion pore with a 1:1 stoichiometry and that binding to open or closed channels is very different. Open-channel properties are revealed by relaxations of partial block during step depolarizations, whereas double-pulse protocols characterize the slower reequilibration of closed-channel binding. |
| Type |
Text |
| Publisher |
Rockefeller University Press |
| First Page |
125 |
| Last Page |
140 |
| Subject |
Conotoxins; k-conotoxin PVIIA; Potassium channel blockers; Shaker K+ channels |
| Subject LCSH |
Conus; Marine toxins; Potassium channels; Potassium -- Antagonists |
| Language |
eng |
| Bibliographic Citation |
Terlau, H., Boccaccio, A., Olivera, B. M., & Conti, F. (1999). Block of Shaker K+ channels by ĸ-conotoxin PVIIA is state dependent. Journal of General Physiology, 114, 125-40. |
| Rights Management |
© Terlau, H., Boccaccio, A., Olivera, B. M., & Conti, F., 1999. Originally published in Journal of General Physiology, 114, 125-40. http://creativecommons.org/licenses/by-nc-sa/3.0/ |
| Format Medium |
application/pdf |
| Format Extent |
372,490 bytes |
| Identifier |
ir-main,8381 |
| ARK |
ark:/87278/s6xh08gn |
| Setname |
ir_uspace |
| ID |
704678 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6xh08gn |
