| Publication Type |
pre-print |
| School or College |
College of Science |
| Department |
Biology |
| Creator |
Capecchi, Mario R. |
| Other Author |
Hill, Kristina E.; Wu, Sen; Motley, Amy K.; Stevenson, Teri D.; Winfrey, Virginia P.; Atkins, John F.; Burk, Raymond F. |
| Title |
Production of selenoprotein P (Sepp1) by hepatocytes is central to selenium homeostasis |
| Date |
2012-01-01 |
| Description |
Background: Sepp1 transports selenium, but its complete role in selenium homeostasis is not known. Results: Deletion of Sepp1 in hepatocytes increases liver selenium at the expense of other tissues and decreases whole-bodyselenium by increasing excretion. Conclusion: Sepp1 production by hepatocytes retains selenium in the organism and distributes it from the liver to peripheral tissues. Significance: Sepp1 is central to selenium homeostasis. |
| Type |
Text |
| Publisher |
American Soc. for Biochemistry and Molecular Biology (ASBMB) |
| Volume |
287 |
| Issue |
48 |
| First Page |
40414 |
| Last Page |
40424 |
| Dissertation Institution |
University of Utah |
| Language |
eng |
| Bibliographic Citation |
Hill, K. E., Wu, S., Motley, A. K., Stevenson, T. D., Winfrey, V. P., Capecchi, M. R., Atkins, J. F., & Burk, R. F. (2012). Production of selenoprotein P (Sepp1) by hepatocytes is central to selenium homeostasis. Journal of Biological Chemistry, 287(48), 40414-24. |
| Rights Management |
©American Society for Biochemistry and Molecular Biology |
| Format Medium |
application/pdf |
| Format Extent |
2,312,363 bytes |
| Identifier |
uspace,18110 |
| ARK |
ark:/87278/s6zg7b18 |
| Setname |
ir_uspace |
| ID |
708282 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6zg7b18 |
