| Publication Type |
journal article |
| School or College |
College of Science |
| Department |
Biology |
| Creator |
Beckerle, Mary C. |
| Other Author |
Kato, Takahiro; Muraski, John; Chen, Yan; Tsujita, Yasuyuki; Wall, Jason; Glembotski, Christopher C.; Schaefer, Erik; Sussman, Mark A. |
| Title |
Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt |
| Date |
2005 |
| Description |
This study delineates a mechanism for antiapoptotic signaling initiated by atrial natriuretic peptide (ANP) stimulation leading to elevation of cGMP levels and subsequent nuclear accumulation of Akt kinase associated with zyxin, a cytoskeletal LIM-domain protein. Nuclear targeting of zyxin induces resistance to cell death coincident with nuclear accumulation of activated Akt. |
| Type |
Text |
| Publisher |
The American Society for Clinical Investigation (ASCI) |
| Volume |
115 |
| Issue |
10 |
| First Page |
2716 |
| Last Page |
2730 |
| Subject |
Zyxin; Akt; Cyclic guanosine monophosphate |
| Subject LCSH |
Atrial natriuretic peptides; Protein kinases; Heart cells; Apoptosis; Adenoviruses; Cyclic nucleotides |
| Language |
eng |
| Bibliographic Citation |
Kato, T., Muraski, J., Chen, Y.,Tsujita, Y., Wall, J., Glembotski, C. C., Schaefer, E., Beckerle, M., & Sussman, M. A. (2005). Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt. Journal of Clinical Investigation, 115(10), 2716-30. |
| Rights Management |
©American Society for Clinical Investigation |
| Format Medium |
application/pdf |
| Format Extent |
2,180,132 bytes |
| Identifier |
ir-main,6608 |
| ARK |
ark:/87278/s664076b |
| Setname |
ir_uspace |
| ID |
705789 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s664076b |
