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Primary chiasmal germinoma. A case report and review of the literature.

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Title Journal of Neuro-Ophthalmology, March 1990, Volume 10, Issue 1
Date 1990-03
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s61c530r
Setname ehsl_novel_jno
ID 226167
Reference URL https://collections.lib.utah.edu/ark:/87278/s61c530r

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Title Primary chiasmal germinoma. A case report and review of the literature.
Creator Browman, C.B.; Farris, B.K.
Affiliation University of Oklahoma College of Medicine, Dean A. McGee Eye Institute, Oklahoma City 73104.
Abstract A case is presented in which an adult man with painless progressive loss of vision subsequently was found to have a primary suprasellar/perichiasmal germinoma (ectopic pinealoma). A review of the literature revealed 93 similar cases of germinoma occurring in the perichiasmal region and these are tabulated. The diagnosis and management of this lesion are discussed, including the recognition of the characteristic neuroendocrinologic triad of diabetes insipidus, visual changes, and hypopituitarism. Of 64 cases from the literature wherein presenting symptoms were reported, 56 (87.5%) had diabetes insipidus, 53 (82.8%) visual changes, and 36 (56%) hypopituitarism. A review of the literature suggests that diabetes insipidus is usually the initial symptom in suprasellar germinoma. However, we wish to emphasize the ophthalmologic presentation of this entity, because of ophthalmologic presentation of this entity, because patients in the age group most affected (adolescents) will often not recognize symptoms of diabetes insipidus, but will first seek medical attention for painless progressive loss of vision suggestive of chiasmal compression. The radiosensitivity of this lesion is also discussed. Of 61 patients receiving irradiation therapy, 42 (68%) were surviving at the time of their individual case report. No patient in the review survived without irradiation therapy.
Subject Adult; Cranial Nerve Neoplasms; Diabetes Insipidus; Dysgerminoma; Humans; Hypopituitarism; Magnetic Resonance Imaging; Male; Optic Chiasm; Testosterone; Tomography, X-Ray Computed; Visual Acuity
OCR Text Show
Format application/pdf
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
Setname ehsl_novel_jno
ID 226144
Reference URL https://collections.lib.utah.edu/ark:/87278/s61c530r/226144
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