Paraneoplastic Optic Neuropathy Associated With Purkinje Cell Antibody-2 in a Patient With Small Cell Lung Cancer

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Title Paraneoplastic Optic Neuropathy Associated With Purkinje Cell Antibody-2 in a Patient With Small Cell Lung Cancer
Creator Jonathan A. Micieli; Edward A. Margolin
Affiliation Department of Ophthalmology and Vision Science, University of Toronto, Toronto, Ontario, Canada
Abstract Paraneoplastic optic neuropathy (PON) is a rare cause of vision loss usually associated with small cell lung cancer. Patients with this condition usually test positive for anti-collapsin response mediating protein-5 (CRMP-5). We describe a case of a 57-year-old woman with bilateral vision loss with the characteristic features of CRMP-5 PON including bilateral optic disc edema and vitreous cells. However, she was negative for anti-CRMP-5 including a negative Western blot on two occasions, but positive for Purkinje Cell Antibody (PCA)-2. Although paraneoplastic antibodies are more predictive of an underlying cancer than a specific syndrome, previously PON has not been associated with PCA-2. Based on this observation, we recommend that the workup should include PCA-2 antibodies in patients who present with bilateral optic neuropathy and vitreous cells.
Subject Female; Humans; Lung Neoplasms / complications; Lung Neoplasms / diagnosis; Middle Aged; Ophthalmoscopy; Optic Nerve Diseases / diagnosis; Optic Nerve Diseases / etiology; Paraneoplastic Syndromes, Ocular; Small Cell Lung Carcinoma / complications; Small Cell Lung Carcinoma / diagnosis
OCR Text Show
Date 2017-03
Format application/pdf
Type Text
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6m4a1c3
Setname ehsl_novel_jno
ID 1938428
Reference URL https://collections.lib.utah.edu/ark:/87278/s6m4a1c3
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