| Publication Type |
Journal Article |
| School or College |
College of Science |
| Department |
Biology |
| Creator |
Olivera, Baldomero M.; Yoshikami, Doju; Bulaj, Grzegorz |
| Other Author |
Buczek, Olga; Jimenez, Elsie C. |
| Title |
Post-translational amino acid isomerization: a functionally important D-amino acid in an excitatory peptide |
| Date |
2005 |
| Description |
The post-translational modification of an L- to a D-amino acid has been documented in relatively few gene products, mostly in small peptides under 10 amino acids in length. In this report, we demonstrate that a 46-amino acid polypeptide toxin has one D-phenylalanine at position 44, and that the epimerization from an L-Phe to a D-Phe has a dramatic effect on the excitatory effects of the peptide. |
| Type |
Text |
| Publisher |
American Society for Biochemistry and Molecular Biology (ASBMB) |
| Volume |
280 |
| Issue |
6 |
| First Page |
4247 |
| Last Page |
4253 |
| Subject |
D-amino acid; Excitatory peptides; Conotoxins |
| Subject LCSH |
Post-translational modification; Isomerization; Excitatory amino acids |
| Language |
eng |
| Bibliographic Citation |
Buczek, O., Yoshikami, D., Bulaj, G., Jimenez, E. C., & Olivera, B. M. (2005). Post-translational amino acid isomerization: a functionally important D-amino acid in an excitatory peptide. Journal of Biological Chemistry, 280(6), 4247-53. |
| Rights Management |
(c)American Society for Biochemistry and Molecular Biology (ASBMB) http://www.asbmb.org/ |
| Format Medium |
application/pdf |
| Format Extent |
365,735 bytes |
| Identifier |
ir-main,8436 |
| ARK |
ark:/87278/s63v01vp |
| Setname |
ir_uspace |
| ID |
707223 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s63v01vp |
