Novel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptors

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Publication Type Journal Article
School or College College of Science
Department Biology
Creator Olivera, Baldomero M.; Bulaj, Grzegorz
Other Author Teichert, Russell W.; Jimenez, Elsie C.; Twede, Vernon; Watkins, Maren; Hollmann, Michael
Title Novel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptors
Date 2007
Description We report the discovery and characterization of three conantokin peptides from the venom of Conus parius. Each peptide (conantokin-Pr1, -Pr2, and -Pr3) contains 19 amino acids with three γ-carboxyglutamate (Gla) residues, a post-translationally modified amino acid characteristic of conantokins. The new peptides contain several amino acid residues that differ from previous conantokin consensus sequences.
Type Text
Publisher American Society for Biochemistry and Molecular Biology (ASBMB)
Volume 282
Issue 51
First Page 36905
Last Page 36913
Subject Conotoxins; Conantokins; Conus parius; Antagonists; n-methyl-D-aspartate receptors
Subject LCSH Conus; Marine toxins
Dissertation Institution University of Utah
Language eng
Bibliographic Citation Teichert, R. W., Jimenez, E. C., Twede, V., Watkins, M., Hollmann, M., Bulaj, G., & Olivera, B. M. (2007). Novel conantokins from Conus parius venom are specific antagonists of N-Methyl-D-aspartate receptors. Journal of Biological Chemistry, 282(51), 36905-13.
Rights Management (c)American Society for Biochemistry and Molecular Biology (ASBMB) http://www.asbmb.org/
Format Medium application/pdf
Format Extent 740,059 bytes
Identifier ir-main,8488
ARK ark:/87278/s6zs3dvf
Setname ir_uspace
ID 704784
Reference URL https://collections.lib.utah.edu/ark:/87278/s6zs3dvf
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