Full-Field Chromatic Pupillometry in the Assessment of the Post-Illumination Pupil Response Driven by Melanopsin-containing Retinal Ganglion Cells

Post-illumination pupil response (PIPR) is produced by the intrinsically photosensitive melanopsin-containing retinal ganglion cells (ipRGCs), and can be measured by chromatic pupillometry. While chromatic pupillometry holds promise as a new diagnostic and outcome measurement tool to assess ipRGC function, current testing protocols use central-field stimulation and require a very bright light of long duration which can be difficult for some subjects. We test the hypothesis that a more robust PIPR can be induced with full-field blue light stimuli of shorter duration and lower intensity than with existing protocols.