Identifier |
20220213_nanos_posters_086 |
Title |
Post-marketing Surveillance of Hearing-related Adverse Events in Patients With TED Treated With Teprotumumab |
Creator |
Kimberly Cockerham; Shayna Melvani; Pamela Rakestraw |
Affiliation |
(KC) Stanford University, Palo Alto, California; (SM) (PR) Horizon Therapeutics, plc, Deerfield, Illinois |
Subject |
Neuro-ophthalmology & Systemic Disease (eg. MS, MG, Thyroid); Graves' Disease |
Description |
Teprotumumab (TEPEZZA), an insulin-like growth factor-1 receptor inhibitor was shown to improve proptosis, diplopia, and inflammation in thyroid eye disease (TED). In the randomized controlled clinical trials, 8/84 (9.5%) of teprotumumab- treated patients reported hearing-related adverse events (AEs) which were mild or moderate in severity, versus no (0.0%) placebo patients.1,2 Hearing-related symptoms have been associated with thyroid abnormalities and autoimmunity although little is known regarding TED, specifically. Here, we discuss AE data reported through post-marketing surveillance in patients exposed to teprotumumab. |
Date |
2022-02 |
Language |
eng |
Format |
application/pdf |
Type |
Text |
Source |
2022 North American Neuro-Ophthalmology Society Annual Meeting |
Relation is Part of |
NANOS Annual Meeting 2022: Poster Session I: Neuro-Ophthalmic Disorders of Neurologic and Systemic Diseases |
Collection |
Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
Holding Institution |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
Rights Management |
Copyright 2022. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
ARK |
ark:/87278/s6drqrw2 |
Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
Setname |
ehsl_novel_nam |
ID |
2062761 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6drqrw2 |