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Ganglion Cell Layer Analysis Unmasks Axonal Loss in Anterior Optic Neuritis

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Title Journal of Neuro-Ophthalmology, June 2015, Volume 35, Issue 2
Date 2015-06
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s66b08p3
Setname ehsl_novel_jno
ID 227735
Reference URL https://collections.lib.utah.edu/ark:/87278/s66b08p3

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Title Ganglion Cell Layer Analysis Unmasks Axonal Loss in Anterior Optic Neuritis
Creator Gema Rebolleda; Elisabet de Dompablo; Francisco J. Muoz-Negrete
Affiliation Department of Ophthalmology, Hospital Universitario Ramn y Cajal, Madrid, Spain
Abstract Optical coherence tomography is a valuable tool for evaluating patients with neuro-ophthalmic disorders. In the acute phase of anterior optic neuritis (ON), peripapillary retinal nerve fiber layer (pRNFL) measurements can underestimate the amount of damage as axonal swelling could mask the true degree of RNFL loss. Contrary to pRNFL evaluation, we hypothesize that macular ganglion cell layer analysis could detect true neuronal loss before swelling resolution in anterior ON. We describe 4 patients with anterior ON in whom ganglion cell layer and inner plexiform layer (GCIPL) thinning was detected earlier than pRNFL loss. GCIPL analysis may provide more accurate information than pRNFL thickness and serve as an early structural indicator of irreversible neuronal loss.
Subject Adult; Axons; Cell Death; Female; Humans; Nerve Fibers; Optic Neuritis; Retinal Ganglion Cells
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Format application/pdf
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
Setname ehsl_novel_jno
ID 227714
Reference URL https://collections.lib.utah.edu/ark:/87278/s66b08p3/227714
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