Fourier-Domain Optical Coherence Tomography and Adaptive Optics Reveal Nerve Fiber Layer Loss and Photoreceptor Changes

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Title Journal of Neuro-Ophthalmology, June 2009, Volume 28, Issue 2
Date 2009-06
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6r246hr
Setname ehsl_novel_jno
ID 225697
Reference URL https://collections.lib.utah.edu/ark:/87278/s6r246hr

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Title Fourier-Domain Optical Coherence Tomography and Adaptive Optics Reveal Nerve Fiber Layer Loss and Photoreceptor Changes
Creator Choi, SS; Zawadzki, RJ; Greiner, MA; Werner, JS; Keltner, JL
Affiliation Department of Ophthalmology and Vision Science, University of California at Davis, Sacramento, California 95817, USA.
Abstract BACKGROUND: New technology allows more precise definition of structural alterations of all retinal layers although it has not been used previously in cases of optic disc drusen. METHODS: Using Stratus and Fourier domain (FD) optical coherence tomography (OCT) and adaptive optics (AO) through a flood-illuminated fundus camera, we studied the retinas of a patient with long-standing optic disc drusen and acute visual loss at high altitude attributed to ischemic optic neuropathy. RESULTS: Stratus OCT and FD-OCT confirmed severe thinning of the retinal nerve fiber layer (RNFL). FD-OCT revealed disturbances in the photoreceptor layer heretofore not described in optic disc drusen patients. AO confirmed the FD-OCT findings in the photoreceptor layer and also showed reduced cone density at retinal locations associated with reduced visual sensitivity. CONCLUSIONS: Based on this study, changes occur not only in the RNFL but also in the photoreceptor layer in optic nerve drusen complicated by ischemic optic neuropathy. This is the first reported application of FD-OCT and the AO to this condition. Such new imaging technology may in the future allow monitoring of disease progression more precisely and accurately.
Subject Adult; Altitude Sickness, complications; Anoxia, complications; Cerebrovascular Circulation, physiology; Fourier Analysis, Humans; Male; Optic Atrophy, etiology; Optic Atrophy, pathology; Optic Atrophy, physiopathology; Optic Disk Drusen, complications; Optic Disk Drusen, pathology; Optic Disk Drusen, physiopathology; Optic Neuropathy, Ischemic, etiology; Optic Neuropathy, Ischemic, pathology; Optic Neuropathy, Ischemic, physiopathology; Optics and Photonics, instrumentation; Photoreceptor Cells, pathology; Retinal Artery, physiopathology; Retinal Cone Photoreceptor Cells, pathology; Retinal Cone Photoreceptor Cells, physiopathology; Retinal Ganglion Cells, pathology; Tomography, Optical Coherence, instrumentation; Tomography, Optical Coherence, methods; Vision, Low, etiology; Vision, Low, pathology; Vision, Low, physiopathology; Visual Fields, physiology
OCR Text Show
Date 2008-06
Format application/pdf
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
Setname ehsl_novel_jno
ID 225688
Reference URL https://collections.lib.utah.edu/ark:/87278/s6r246hr/225688
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