Visual Activation in Functional Magnetic Resonance Imaging at Very High Field

Update Item Information
Title Journal of Neuro-Ophthalmology, March 2001, Volume 21, Issue 1
Date 2001-03
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6768mdm
Setname ehsl_novel_jno
ID 225148
Reference URL https://collections.lib.utah.edu/ark:/87278/s6768mdm

Page Metadata

Title Visual Activation in Functional Magnetic Resonance Imaging at Very High Field
Creator Miki, A; Liu, GT; Raz, J; Englander, SA; Bonhomme, GR; Aleman, DO; Modestino, EJ; Liu, CS; Haselgrove, JC
Affiliation Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia 19104, USA.
Abstract OBJECTIVES: Functional magnetic resonance imaging (fMRI) at very high field strengths provides functional brain mapping with the enhanced signal to noise ratio and the larger blood oxygenation level-dependent (BOLD) effect. We report activated areas in the standard space detected by fMRI at 4 Tesla (T) during simple visual stimulation. MATERIALS AND METHODS: Twelve healthy young subjects were scanned using a 4 T scanner during binocular flashing visual stimulation. Functional images were realigned to the first scan and then spatially normalized. Individual and group data analyses were performed to identify areas of visual activation. RESULTS: Activation of the bilateral primary visual cortex (V1/V2) was observed along the entire calcarine fissure in all subjects. The activated area extended to the extrastriate cortex in all subjects. Activation of the bilateral lateral geniculate nucleus (LGN) was detected in all subjects. The group data showed activation of the bilateral primary visual cortex and the bilateral lateral geniculate nucleus. CONCLUSIONS: Robust activation of the vision-related areas was successfully obtained in all subjects using a 4 T magnetic resonance scanner. These results suggest that fMRI at very high field strengths may be effective in showing visual system physiology, and that it can be a promising method to assess visual function of human subjects.
Subject Adult; Brain Mapping; Female; Geniculate Bodies/physiology; Humans; Magnetic Resonance Imaging/methods; Male; Photic Stimulation; Vision, Binocular/physiology; Visual Cortex/physiology
OCR Text Show
Format application/pdf
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
Setname ehsl_novel_jno
ID 225132
Reference URL https://collections.lib.utah.edu/ark:/87278/s6768mdm/225132
Back to Search Results