Publication Type |
Journal Article |
School or College |
College of Science |
Department |
Biology |
Creator |
Olivera, Baldomero M. |
Other Author |
Platt, Randall J.; Han, Tiffany S.; Green, Brad R.; Smith, Misty D.; Skalicky, Jack; Gruszczyński, Pawel; White, H. Steve; Bulaj, Grzegorz; Gajewiak, Joanna |
Title |
Stapling mimics noncovalent interactions of γ-carboxyglutamates in conantokins, peptidic antagonists of N-methyl-D-aspartic acid receptors |
Date |
2012-01-01 |
Description |
Background: Can dicarba bridges (stapling) replace noncovalent interactions that stabilize helical conformation of neuroactivepeptides? Results: A rational design, synthesis, structural, and functional characterization of stapled conG analogs that target NMDAreceptors is reported. Conclusion: Stapled conG analogs are potent antagonists of NMDA receptors and anticonvulsant compounds. Significance: Stapling can be successfully applied to convert neuroactive peptides into drug leads. |
Type |
Text |
Publisher |
American Soc. for Biochemistry and Molecular Biology (ASBMB) |
Volume |
287 |
Issue |
24 |
First Page |
20727 |
Last Page |
20736 |
Dissertation Institution |
University of Utah |
Language |
eng |
Bibliographic Citation |
Platt, R. J., Han, T. S., Green, B. R., Smith, M. D., Skalicky, J., Gruszczyński, P., White, H. S., Olivera, B., Bulaj, G., & Gajewiak, J. (2012). Stapling mimics noncovalent interactions of γ-carboxyglutamates in conantokins, peptidic antagonists of N-methyl-D-aspartic acid receptors. Journal of Biological Chemistry, 287(24), 20727-36. |
Rights Management |
(c)American Society for Biochemistry and Molecular Biology (ASBMB) http://www.asbmb.org/ |
Format Medium |
application/pdf |
Format Extent |
463,045 bytes |
Identifier |
uspace,17534 |
ARK |
ark:/87278/s6kh162q |
Setname |
ir_uspace |
ID |
708046 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6kh162q |