| Publication Type |
Journal Article |
| School or College |
College of Science |
| Department |
Biology |
| Creator |
Olivera, Baldomero M.; Zhang, MinMin; Azam, Layla; Yoshikami, Doju; Bulaj, Grzegorz |
| Other Author |
Green, Brad R.; Catlin, Philip; Fiedler, Brian; Chadwick, Ashley; Terlau, Heinrich; McArthur, Jeff R.; French, Robert J.; Gulyas, Josef; Rivier, Jean E.; Smith, Brian J.; Norton, Raymond S. |
| Title |
Structure/function characterization of μ-Conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels |
| Date |
2007 |
| Description |
Peptide neurotoxins from cone snails continue to supply compounds with therapeutic potential. Although several analgesic conotoxins have already reached human clinical trials, a continuing need exists for the discovery and development of novel nonopioid analgesics, such as subtype-selective sodium channel blockers. |
| Type |
Text |
| Publisher |
American Society for Biochemistry and Molecular Biology (ASBMB) |
| Volume |
282 |
| Issue |
42 |
| First Page |
30699 |
| Last Page |
30706 |
| Subject |
Conotoxins; 956;-Conotoxin KIIIA; Neuronal blocker; Neurotoxins; Sodium channel blockers |
| Subject LCSH |
Conus; Marine toxins; Sodium channels; Sodium -- Antagonists |
| Language |
eng |
| Bibliographic Citation |
Zhang, M.-M., Green, B. R., Catlin, P., Fiedler, B., Azam, L., Chadwick, A., Terlau, H., McArthur, J. R., French, R. J., Gulyas, J., Rivier, J. E., Smith, B. J., Norton, R. S., Olivera, B. M., Yoshikami, D., & Bulaj, G. (2007). Structure/function characterization of μ-Conotoxin KIIIA, an analgesis, nearly irreversible blocker of mammalian neuronal sodium channels. Journal of Biological Chemistry, 282(42), 30699-706. |
| Rights Management |
(c)American Society for Biochemistry and Molecular Biology (ASBMB) http://www.asbmb.org/ |
| Format Medium |
application/pdf |
| Format Extent |
432,648 bytes |
| Identifier |
ir-main,8490 |
| ARK |
ark:/87278/s62j6w4g |
| Setname |
ir_uspace |
| ID |
704028 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s62j6w4g |
