Two Patients with Parinaud's Syndrome with Slow Upward Saccades and Normal Upward Range of Movements

Presented here are two patients with Parinaud's syndrome: Patient 1) suffered a hemorrhage of the dorsal midbrain causing slow upward saccades (with convergence retraction nystagmus, but normal vertical range of eye movements), and light-near dissociation, and Patient 2) had a germinoma of the dorsal midbrain with light-near dissociation, partial right 3rd nerve palsy , slow upward saccades and upbeat nystagmus in upgaze (from presumed interstitial nucleus of Cajal involvement, which is the vertical neural integrator). Parinaud's syndrome may selectively involve upward saccades while sparing other classes of upward eye movements.