| Identifier |
20230314_nanos_posters_297 |
| Title |
VRDN-001, a Full Antagonist Antibody to IGF-1 Receptor in Development for Thyroid Eye Disease (TED), Binds to a Distinct Epitope from Teprotumumab |
| Creator |
Yang Zhao; Jordan Tsai; Rachel Newell; Vahe Bedian |
| Affiliation |
(YZ) (JT) (RN) (VB) Viridian Therapeutics Inc. |
| Subject |
Graves' Disease; Neuro-ophth & Systemic Disease (eg. MS, MG, Thyroid); Orbit/ocular Pathology |
| Description |
VRDN-001, a full antagonist antibody to the insulin-like growth factor-1 receptor (IGF-1R), is under development for the treatment of thyroid eye disease (TED). Clinical and preclinical studies have confirmed IGF-1R antagonism can reduce the inflammation and proptosis that occur in TED. As different anti-IGF-1R antibodies may have distinct characteristics, we compared the binding epitope and in vitro antagonist properties of VRDN-001 with teprotumumab. |
| Date |
2023-03-14 |
| Language |
eng |
| Format |
application/pdf |
| Type |
Text |
| Source |
2023 North American Neuro-Ophthalmology Society Annual Meeting |
| Relation is Part of |
NANOS Annual Meeting 2023: Poster Session II: Neuro-Ophthalmic Disorders of Neurologic and Systemic Diseases |
| Collection |
Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
| Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Holding Institution |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
| Rights Management |
Copyright 2023. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK |
ark:/87278/s63a9yzr |
| Setname |
ehsl_novel_nam |
| ID |
2335502 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s63a9yzr |
