| Publication Type |
pre-print |
| School or College |
College of Science |
| Department |
Biology |
| Creator |
Olivera, Baldomero M. |
| Other Author |
Safavi-Hemami, Helena; Gorasia, Dhana G.; Steiner, Andrew M.; Williamson, Nicholas A.; Karas, John A.; Gajewiak, Joanna; Bulaj, Grzegorz; Purcell, Anthony W. |
| Title |
Modulation of conotoxin structure and function is achieved through a multienzyme complex in the venom glands of cone snails |
| Date |
2012-01-01 |
| Description |
Background: Conotoxins can be utilized to investigate enzyme-assisted folding of disulfide-rich peptides. Results: Various ER-resident cone snail enzymes act in concert to accelerate the oxidative folding of conotoxins and modulate their conformation by reconfiguring disulfide connectivities. Conclusion: The folding of conotoxins is a tightly regulated multienzyme-assisted process. Significance: Modulation of the conformation of conotoxins increases their molecular and functional diversity. |
| Type |
Text |
| Publisher |
American Soc. for Biochemistry and Molecular Biology (ASBMB) |
| Volume |
287 |
| Issue |
41 |
| First Page |
34288 |
| Last Page |
34303 |
| Dissertation Institution |
University of Utah |
| Language |
eng |
| Bibliographic Citation |
Safavi-Hemami, H., Gorasia, D. G., Steiner, A. M., Williamson, N. A., Karas, J. A., Gajewiak, J., Olivera, B. M., Bulaj, G., & Purcell, A. W. (2012). Modulation of conotoxin structure and function is achieved through a multienzyme complex in the venom glands of cone snails. Journal of Biological Chemistry, 287(41), 34288-303. |
| Rights Management |
(c)American Society for Biochemistry and Molecular Biology (ASBMB) http://www.asbmb.org/ |
| Format Medium |
application/pdf |
| Format Extent |
2,731,950 bytes |
| Identifier |
uspace,17962 |
| ARK |
ark:/87278/s6z03sxz |
| Setname |
ir_uspace |
| ID |
708198 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6z03sxz |
