Surprisingly uneven distribution of the T cell receptor Vβ repertoire in wild mice

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Publication Type Journal Article
School or College College of Science
Department Biology
Creator Potts, Wayne K.
Other Author Pullen, Ann M.; Wakeland, Edward K.; Kappler, John; Marrack, Philippa
Title Surprisingly uneven distribution of the T cell receptor Vβ repertoire in wild mice
Date 1990
Description Heterodimeric TCRa/Bs are made up of combinations of V D, J, and C elements. The majority of laboratory inbred mouse strains are of the VBh haplotype and have at least 20 VB genes from which to construct TCRs (1, 2); however, a number of strains have been reported to have deletions of large portions of the VB locus on chromosome 6 (3-5), and these mice must survive with a considerably reduced potential TCR repertoire.
Type Text
Publisher Rockefeller University Press
First Page 49
Last Page 62
Language eng
Bibliographic Citation Pullen, A, M., Potts, W. K., Wakeland, E. K., Kappler, J., & Marrack, P. (1990). Surprisingly uneven distribution of the T cell receptor Vβ repertoire in wild mice. Journal of Experimental Medicine, 171, Jan., 49-62.
Rights Management (c)Pullen, A, M., Potts, W. K., Wakeland, E. K., Kappler, J., & Marrack, P. http://www.jcb.org/
Format Medium application/pdf
Format Extent 1,022,260 bytes
Identifier ir-main,6051
ARK ark:/87278/s6bp0m4r
Setname ir_uspace
ID 704667
Reference URL https://collections.lib.utah.edu/ark:/87278/s6bp0m4r
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