| Publication Type |
Journal Article |
| School or College |
College of Science |
| Department |
Biology |
| Creator |
Jorgensen, Erik |
| Other Author |
Nonet, Michael L.; Staunton, Jane E.; Kilgard, Michael P.; Fergestad, Tim; Hartwieg, Erika; Horvitz, H. Robert; Meyer, Barbara J. |
| Title |
Caenorhabditis elegans rab-3 mutant synapses exhibit impaired function and are partially depleted of vesicles |
| Date |
1997 |
| Description |
Rab molecules regulate vesicular trafficking in many different exocytic and endocytic transport pathways in eukaryotic cells. In neurons, rab3 has been proposed to play a crucial role in regulating synaptic vesicle release. To elucidate the role of rab3 in synaptic transmission, we isolated and characterized Caenorhabditis elegans rab-3 mutants. Similar to the mouse rab3A mutants, these mutants survived and exhibited only mild behavioral abnormalities. In contrast to the mouse mutants, synaptic transmission was perturbed in these animals. |
| Type |
Text |
| Publisher |
Society for Neuroscience |
| Volume |
17 |
| Issue |
21 |
| First Page |
8061 |
| Last Page |
8073 |
| Language |
eng |
| Bibliographic Citation |
Nonet, M. L., Staunton, J. E., Kilgard, M., Fergestad, T., Hartwieg, E., Horvitz, H. R., Jorgensen, E., & Meyer, B. J. (1997). Caenorhabditis elegans rab-3 mutant synapses exhibit impaired function and are partially depleted of vesicles. Journal of Neuroscience, 17(21), 8061-73. |
| Rights Management |
(c) Society for Neuroscience http://www.jneurosci.org/ |
| Format Medium |
application/pdf |
| Format Extent |
1,009,331 bytes |
| Identifier |
ir-main,6319 |
| ARK |
ark:/87278/s60k2sq2 |
| Setname |
ir_uspace |
| ID |
702901 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s60k2sq2 |
