Publication Type |
Journal Article |
School or College |
College of Science |
Department |
Biology |
Creator |
Capecchi, Mario R.; Thomas, Kirk R. |
Other Author |
Folger, Kim R. |
Title |
High frequency targeting of genes to specific sites in the mammalian genome |
Date |
1986 |
Description |
We corrected a defective gene residing in the chromosome of a mammalian cell by injecting into the nucleus copies of the same gene carrying a different mutation. We determined how the number, the arrangement, and the chromosomal position of the integrated gene, as well as the number of injected molecules influence the gene-targeting frequency. |
Type |
Text |
Publisher |
MIT Press |
Volume |
44 |
First Page |
419 |
Last Page |
428 |
Subject |
Homologous recombination; Mutant genes; Mammalian genome |
Subject LCSH |
Gene targeting; Recombinant DNA; Mutation (Biology) |
Language |
eng |
Bibliographic Citation |
Thomas, K. R., Folger, K. R., & Capecchi, M. R. (1986). High frequency targeting of genes to specific sites in the mammalian genome. Cell, 44, 419-28. |
Rights Management |
(c) MIT Press http://mitpress.mit.edu/ |
Format Medium |
application/pdf |
Format Extent |
2,488,700 bytes |
Identifier |
ir-main,8972 |
ARK |
ark:/87278/s67p9h1n |
Setname |
ir_uspace |
ID |
706809 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s67p9h1n |