| Title |
Identifying RNAs from Invading Viruses |
| Creator |
Bass, B.L.; Shen, P.; Iwasa, J. |
| Subject |
Diffusion of Innovation; Viruses; DICER1 protein, human; DEAD-box RNA Helicases; RNA, Double-Stranded; RNA, Viral; Ribonuclease III; eIF-2 Kinase; Gene Expression Regulation;Host-Pathogen Interactions; Gene Expression Regulation; Gene Expression Regulation, Viral; Antiviral Agents; Invertebrates; Knowledge Discovery |
| Keyword |
Fundamental Biology |
| Image Caption |
Dicer discriminates dsRNA with overhanging termini (self) from viral dsRNA (non-self). |
| Description |
Organisms must regulate gene expression and also distinguish their RNA molecules (self) from the RNAs of invading viruses (non-self). Biochemical and structural studies from Bass, Shen, Iwasa, and colleagues revealed how Dicer-2, an RNA processing, and antiviral defense enzyme, distinguishes and differentially processes double-stranded RNA (dsRNA) substrates by sensing the unique chemistry at their termini. The study also revealed that human Dicer evolved with distinct activities from invertebrate Dicers, and this discovery is paving the way for altering the antiviral defense for therapeutic benefits. |
| Relation is Part of |
2018 |
| Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Date Digital |
2020 |
| Date |
2018 |
| Type |
Image |
| Format |
image/jpeg |
| Rights Management |
Copyright © 2021, University of Utah, All Rights Reserved |
| Language |
eng |
| ARK |
ark:/87278/s6w43kdh |
| References |
1.) Dicer uses distinct modules for recognizing dsRNA termini. Sinha NK, Iwasa J, Shen PS, Bass BL. Science. 2018 Jan;359(6373):329 https://pubmed.ncbi.nlm.nih.gov/29269422/ |
| Press Releases and Media |
Detecting & Destroying Intruders https://attheu.utah.edu/facultystaff/detecting-destroying-intruders/; ScienceDaily https://www.sciencedaily.com/releases/2017/12/171221143114.htm; Genetic Engineering and Biotechnology News https://www.genengnews.com/topics/omics/team-shows-how-dicer-protein-detects-and-destroys-viral-invaders/ |
| Setname |
ehsl_50disc |
| ID |
1589379 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6w43kdh |
