Publication Type |
pre-print |
School or College |
School of Medicine |
Department |
Neurosurgery |
Creator |
Couldwell, William T. |
Other Author |
Sivakumar, Walavan |
Title |
Pituitary models |
Date |
2013-01-01 |
Description |
Pituitary tumor animal models provide researchers a microenvironment that simulates the clinical situation; however, in comparison with astrocytoma and meningioma tumor research where intracranial xenograft transplantations are increasingly being used to test various therapeutic modalities, in vivo therapeutic research on pituitary animal models focuses on direct drug therapy to the tumor because of the lack of established intracranial pituitary tumor models. The rat subcutaneous prolactin-secreting pituitary model allows investigators to noninvasively measure tumor size and the effect of direct tumor-guided therapy in a serial manner and is considered biologically relevant because it has proven to be histologically, immunocytochemically, and ultrastructurally consistent with human pituitary tumors. |
Type |
Text |
Publisher |
Springer |
Volume |
77 |
First Page |
175 |
Last Page |
179 |
Language |
eng |
Bibliographic Citation |
Sivakumar, W., & Couldwell, W. T. (2013). Pituitary models. Neuromethods, 77, 175-9. |
Rights Management |
(c) Springer (The original publication is available at www.springerlink.com) ; DOI: 10.1007/7657_2011_28. |
Format Medium |
application/pdf |
Format Extent |
798,202 bytes |
Identifier |
uspace,18157 |
ARK |
ark:/87278/s6tf0g5g |
Setname |
ir_uspace |
ID |
708345 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6tf0g5g |