| Publication Type |
Journal Article |
| School or College |
College of Science |
| Department |
Biology |
| Creator |
Olivera, Baldomero M.; McIntosh, J. Michael |
| Other Author |
Corpuz, Gloria O.; Layer, Richard T.; Garrett, James E.; Wagstaff, John D.; Bulaj, Grzegorz; Vyazovkina, Alexandra; Yoshikami, Doju; Cruz, Lourdes J. |
| Title |
Isolation and characterization of a novel Conus peptide with apparent antinociceptive activity |
| Date |
2000 |
| Description |
Cone snails are tropical marine mollusks that envenomate prey with a complex mixture of neuropharmacologically active compounds. We report the discovery and biochemical characterization of a structurally unique peptide isolated from the venom of Conus marmoreus. The new peptide, mr10a, potently increased withdrawal latency in a hot plate assay (a test of analgesia) at intrathecal doses that do not produce motor impairment as measured by rotarod test. |
| Type |
Text |
| Publisher |
American Society for Biochemistry and Molecular Biology (ASBMB) |
| Volume |
275 |
| Issue |
42 |
| First Page |
32391 |
| Last Page |
32397 |
| Subject |
Conotoxins; Conus peptides; Conus marmoreus; mr10a; antinociceptive activity |
| Subject LCSH |
Conus; Marine toxins; Analgesia |
| Language |
eng |
| Bibliographic Citation |
McIntosh, J. M., Corpuz, G. O., Layer, R. T., Garrett, J. E., Wagstaff, J. D., Bulaj, G., Vyazovkina, A., Yoshikami, D., Cruz, L. J., & Olivera, B. M. (2000). Isolation and characterization of a novel Conus peptide with apparent antinociceptive activity. Journal of Biological Chenmistry, 275(42), 32391-97. |
| Rights Management |
(c)American Society for Biochemistry and Molecular Biology (ASBMB) http://www.asbmb.org/ |
| Format Medium |
application/pdf |
| Format Extent |
269,624 bytes |
| Identifier |
ir-main,8400 |
| ARK |
ark:/87278/s64j0zpt |
| Setname |
ir_uspace |
| ID |
706304 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s64j0zpt |
