| Publication Type |
Journal Article |
| School or College |
College of Science |
| Department |
Biology |
| Creator |
Olivera, Baldomero M. |
| Other Author |
Verdier, Laurent; Al-Sabi, Ahmed; Rivier, Jean E. F.; Terlau, Heinrich; Carlomagno, Teresa |
| Title |
Identification of a novel pharmacophore for peptide toxins interacting with K+ channels |
| Date |
2005 |
| Description |
қM-conotoxin RIIIK blocks TSha1 K+ channels from trout with high affinity by interacting with the ion channel pore. As opposed to many other peptides targeting K+ channels, қM-RIIIK does not possess a functional dyad. In this study we combine thermodynamic mutant cycle analysis and docking calculations to derive the binding mode of қM-conotoxin RIIIK to the TSha1 channel. |
| Type |
Text |
| Publisher |
American Society for Biochemistry and Molecular Biology (ASBMB) |
| Volume |
280 |
| First Page |
21246 |
| Last Page |
21255 |
| Subject |
Conotoxins; Peptide toxins; қM-conotoxin RIIIK; Pharmacophore |
| Subject LCSH |
Conus; Marine toxins; Potassium channels |
| Language |
eng |
| Bibliographic Citation |
Verdier, L., Al-Sabi, A., Rivier, J. E., Olivera, B. M.,Terlau, H., & Carlomagno, T. (2005). Identification of a novel pharmacophore for peptide toxins interacting with K+ channels. Journal of Biological Chemistry, 280, 21246-55. |
| Rights Management |
(c)American Society for Biochemistry and Molecular Biology (ASBMB) http://www.asbmb.org/ |
| Format Medium |
application/pdf |
| Format Extent |
875,110 bytes |
| Identifier |
ir-main,8458 |
| ARK |
ark:/87278/s6kk9w18 |
| Setname |
ir_uspace |
| ID |
703441 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6kk9w18 |
