| Publication Type |
Journal Article |
| School or College |
College of Science |
| Department |
Biology |
| Creator |
Olivera, Baldomero M.; ; McIntosh, J. Michael |
| Other Author |
Albensi, Benedict C.; Ryujin, Kevin T.; Naisbitt, S. R.; Fillous, F. |
| Title |
Localization of [125I] ω-conotoxin GVIA binding in human hippocampus and cerebellum |
| Date |
1993 |
| Description |
THE peptide toxin ω-conotoxin GVIA (ω-CgTx) has been shown to be a high affinity ligand for N-type calcium channels in the brain. We have employed [125I]ω-CgTx to localize N-type channels in human hippocampus and cerebellum using autoradiography. Ten micron thick slidemounted tissue sections of human cerebellum and hippocampus were labeled with [125I]ω-CgTx under various conditions. Specific binding t o human cerebellum was virtually irreversible and saturable. |
| Type |
Text |
| Publisher |
Wolters Kluwer (LWW) |
| Volume |
4 |
| Issue |
12 |
| First Page |
1331 |
| Last Page |
1334 |
| Subject |
Conotoxins; Peptide toxins |
| Subject LCSH |
Conus; Marine toxins; Calcium -- Antagonists; Calcium channels; Hippocampus (Brain); Cerebellum |
| Language |
eng |
| Bibliographic Citation |
Albensi, B. C., Ryujin, K. T., McIntosh, J. M., Naisbitt, S. R., Olivera, B. M., & Fillous, F. (1993). Localization of [125I] ω-conotoxin GVIA binding in human hippocampus and cerebellum. NeuroReport, 4(12), 1331-4. |
| Rights Management |
(c) Wolters Kluwer (LWW) |
| Format Medium |
application/pdf |
| Format Extent |
1,591,027 bytes |
| Identifier |
ir-main,8329 |
| ARK |
ark:/87278/s6qn6r0z |
| Setname |
ir_uspace |
| ID |
703172 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6qn6r0z |
