| Publication Type |
Journal Article |
| School or College |
College of Science; School of Medicine |
| Department |
Oncological Sciences; Biology; Human Genetics |
| Program |
Institute of Human Genetics; Howard Hughes Medical Institute (HHMI) |
| Creator |
Capecchi, Mario R. |
| Other Author |
Frels, William I.; Bluestone Jeffery A; Hodes, Richard J; Singer Dinah S. |
| Title |
Expression of a microinjected porcine class I major histocompatibility complex gene in transgenic mice. |
| Date |
1985-05-03 |
| Description |
A porcine class I major histocompatibility complex (SLA) gene has been introduced into the genome of a C57BL/10 mouse. This transgenic mouse expressed SLA antigen on its cell surfaces and transmitted the gene to offspring, in which the gene is also expressed. Skin grafts of such transgenic mice were rejected by normal C57BL/10 mice, suggesting that the foreign SLA antigen expressed in the transgenic mice is recognized as a functional transplantation antigen. |
| Type |
Text |
| Publisher |
American Association for the Advancement of Science (AAAS) |
| Volume |
228 |
| Issue |
4699 |
| First Page |
577 |
| Last Page |
580 |
| Subject |
Genetic Engineering; Graft Rejection; Mice, Inbred C57BL |
| Subject MESH |
Major Histocompatibility Complex; Nucleic Acid Hybridization; Skin Transplantation |
| Language |
eng |
| Bibliographic Citation |
Science. 1985 May 3;228(4699):577-80. Frels WI, Bluestone JA, Hodes RJ, Capecchi MR, Singer DS. Expression of a microinjected porcine class I major histocompatibility complex gene in transgenic mice. Retrieved on November 1 2006 from http://www.sciencemag.org/cgi/reprint/228/4699/577. |
| Rights Management |
copyright © 1985 American Association for the Advancement of Science. All Rights Reserved. |
| Format Medium |
application/pdf |
| Identifier |
ir-main,525 |
| ARK |
ark:/87278/s6qj81v6 |
| Setname |
ir_uspace |
| ID |
706460 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6qj81v6 |
