| Publication Type |
Journal Article |
| School or College |
College of Science |
| Department |
Biology |
| Creator |
Beckerle, Mary C.; Hoffman, Laura M. |
| Other Author |
Takizawa, Norio; Smith,Tara C.; Nebl, Thomas; Crowley, Jessica L.; Palmeiri, Stephen J.; Lifshitz, Lawrence M.; Ehrhardt, Anka G.; Luna, Elizabeth J. |
| Title |
Supervillin modulation of focal adhesions involving TRIP6/ZRP-1 |
| Date |
2006 |
| Description |
Cell-substrate contacts, called focal adhesions (FAs), are dynamic in rapidly moving cells. We show that supervillin (SV)-a peripheral membrane protein that binds myosin II and F-actin in such cells-negatively regulates stress fibers, FAs, and cell-substrate adhesion. The major FA regulatory sequence within SV (SV342-571) binds to the LIM domains of two proteins in the zyxin family, thyroid receptor-interacting protein 6 (TRIP6) and lipoma-preferred partner (LPP), but not to zyxin itself. |
| Type |
Text |
| Publisher |
Rockefeller University Press |
| Volume |
174 |
| Issue |
3 |
| First Page |
447 |
| Last Page |
458 |
| Subject |
Supervillin; Focal adhesions; Zyxin; LIM domains; TRIP6 |
| Subject LCSH |
Cell adhesion; Membrane proteins; Cytoskeletal proteins |
| Language |
eng |
| Bibliographic Citation |
Takizawa, N., Smith,T. C., Nebl, T., Crowley, J. L., Palmeiri, S. J., Lifshitz, L. M., Ehrhardt, A. G., Hoffman, L. M., Beckerle, M. C., & Luna, E. J. (2006). Supervillin modulation of focal adhesions involving TRIP6/ZRP-1. Journal of Cell Biology, 174(3), 447-58. |
| Rights Management |
(c)Takizawa, N., Smith,T. C., Nebl, T., Crowley, J. L., Palmeiri, S. J., Lifshitz, L. M., Ehrhardt, A. G., Hoffman, L. M., Beckerle, M. C., & Luna, E. J., 2006. Originally published in J. Cell Biol., 174(3), 447-58. http://creativecommons.org/licenses/by-nc-sa/3.0/ |
| Format Medium |
application/pdf |
| Format Extent |
4,008,500 bytes |
| Identifier |
ir-main,6619 |
| ARK |
ark:/87278/s6sx6xpc |
| Setname |
ir_uspace |
| ID |
705792 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6sx6xpc |
