Publication Type |
Journal Article |
School or College |
College of Engineering |
Department |
Bioengineering |
Creator |
Christensen, Douglas A. |
Other Author |
Rapoport, Natalya Y.; Gao, Zhonggao; Kamaev, Pavel |
Title |
Ultrasound-enhanced localized chemotherapy of drug-sensitive and multidrug resistant tumors |
Date |
2006 |
Description |
A new modality of targeted tumor chemotherapy is based on the drug encapsulation in polymeric nanoparticles followed by a localized release at the tumor site triggered by focused ultrasound. Effect of 1 MHz and 3 MHz unfocused ultrasound applied locally to the tumor on the Doxorubicin (DOX) biodistribution and tumor growth rates was measured for ovarian carcinoma tumors in nu/nu mice. The bioeffects of ultrasound were investigated on the systemic and cellular levels. Growth rates of A2780 ovarian carcinoma tumors were substantially reduced by combining micellar drug delivery with tumor irradiation. Ultrasound effect was not thermal as manifested by intratumoral temperature measurements during sonication. Biodistribution studies showed that ultrasound did not enhance micelle extravasation. Main mechanisms of the ultrasound-enhanced chemotherapy included (i) passive targeting of drug-loaded micelles to the tumor interstitium; (ii) ultrasound-triggered localized drug release from micelles in the tumor volume; (iii) enhanced micelle and drug diffusion through the tumor interstitium; and (iv) ultrasound-triggered cell membrane damage resulting in the enhanced micelle and drug uptake by tumor cells. |
Type |
Text |
Publisher |
American Institute of Physics (AIP) |
Volume |
829 |
First Page |
481 |
Last Page |
485 |
DOI |
10.1063/1.2205521 |
citatation_issn |
0094243X |
Subject |
Ultrasound-enhanced chemotherapy; Drug-resistant tumors; Biodistribution; Tumor sonication |
Subject LCSH |
Chemotherapy; Ovaries -- Cancer -- Treatment; Colon (Anatomy) -- Cancer -- Treatment |
Subject MESH |
Ultrasonography |
Language |
eng |
Conference Title |
THERAPEUTIC ULTRASOUND: 5th International Symposium on Therapeutic Ultrasound; 27-29 October 2005; Boston, Massachusetts (USA) |
Bibliographic Citation |
Rapoport, N. Y., Gao, Z., Kamaev, P., & Christensen, D. A. (2006). Ultrasound-enhanced localized chemotherapy of drug-sensitive and multidrug resistant tumors. AIP Conference Proceedings, 829, 481-5. |
Rights Management |
(c)American Institute of Physics. The following article appeared in Rapoport, N. Y., Gao, Z., Kamaev, P., & Christensen, D. A., AIP Conference Proceedings, 829, 2006 and may be found at http://dx.doi.org/10.1063/1.2205521 |
Format Medium |
application/pdf |
Format Extent |
262,958 bytes |
Identifier |
ir-main,11648 |
ARK |
ark:/87278/s6v41cdz |
Setname |
ir_uspace |
ID |
703613 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6v41cdz |