Publication Type |
Journal Article |
School or College |
School of Medicine |
Department |
Neurosurgery |
Creator |
Couldwell, William T. |
Other Author |
Weiss, Martin H.; DeGiorgio, Christopher M.; Weiner, Leslie P.; Hinton, David R.; Ehresmann, Glenn R.; Conti, Peter S.; Apuzzo, Michael L. J. |
Title |
Clinical and radiographic response in a minority of patients with recurrent malignant gliomas treated with high-dose tamoxifen |
Date |
1993 |
Description |
PREVIOUS WORK HAS demonstrated the importance of the Protein Kinase C (PKC) signal transduction system in regulating the growth rate of malignant gliomas in vitro. Tamoxifen inhibits PKC in a minority of malignant gliomas within the micromolar concentration range in vitro, a property distinct from its estrogen receptor blockade effect. Tamoxifen was administered orally in very high dosages to 11 patients (9 males:2 females, age range 26-73, mean 45 years) with malignant gliomas (anaplastic astrocytoma or glioblastoma multiforme) who had failed treatment with external beam radiation therapy (and additional chemotherapy in 2). The dosage administered was estimated to be that necessary to achieve tissue concentrations within the low micromolar range, shown necessary to inhibit PKC in these tumors in vitro, and is approximately 5 times that used for standard antiestrogen therapy. |
Type |
Text |
Publisher |
Wolters Kluwer (LWW) |
Volume |
32 |
Issue |
3 |
First Page |
485 |
Last Page |
490 |
Subject |
Tamoxifen; Protein kinase C; Glioma; Brain neoplasm; Chemotherapy; Glioma |
Subject LCSH |
Gliomas; Protein kinases; Brain -- Cancer |
Language |
eng |
Bibliographic Citation |
Couldwell, W. T., Weiss, M. H., DeGiorgio, C. M., Weiner, L. P., Hinton, D. R., Ehresmann, G. R., Conti, P. S., & Apuzzo, M. L. J. (1993). Clinical and radiographic response in a minority of patients with recurrent malignant gliomas treated with high-dose tamoxifen. Neurosurgery, 32(3), 485-90. |
Rights Management |
(c) Wolters Kluwer (LWW) |
Format Medium |
application/pdf |
Format Extent |
912,874 bytes |
Identifier |
ir-main,12501 |
ARK |
ark:/87278/s6mc9h7n |
Setname |
ir_uspace |
ID |
703669 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6mc9h7n |