Paraneoplastic Anti-Hu and Anti-CV2 Positive Ataxic (Cerebellar and Sensory Ganglionopathy) Encephalitis

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Identifier Paraneoplastic_Anti-Hu_and_Anti-CV2_positive_ataxic_cerebellar_and_sensory_ganglionopathy_encephalitis
Title Paraneoplastic Anti-Hu and Anti-CV2 Positive Ataxic (Cerebellar and Sensory Ganglionopathy) Encephalitis
Creator Anuj Rastogi; Rahul Sharma; Gustavo Saposnik; Alexandra Muccilli
Affiliation (AR) Neurology, University of Toronto; (RS) Ophthalmology, University of Toronto; (GS) Neurology, University of Toronto; (AM) Neurology, University of Toronto
Subject Anti-CV2; Anti-Hu; Ataxia; Cerebellar Ataxia; Encephalitis; Nystagmus; Sensory Ganglionopathy
Description We describe a case of an elderly man with Non-small Cell Lung Cancer, presenting with paraneoplastic Anti-Hu and Anti-CV2 positive encephalitis. He had both cerebellar ataxia and sensory ataxia, likely from the paraneoplastic induced cerebellar degeneration and sensory ganglionopathy, respectively. We describe the patient history, examination findings, including pertinent oculomotor abnormalities, and general management for these kinds of patients. We further discuss paraneoplastic cerebellar degeneration and autoimmune encephalitis as it relates to ataxia.
Date 2024-03
References Amato AA, Ropper AH. Sensory Ganglionopathy. N Engl J Med. 2020 Oct 22;383(17):1657-1662.​ Aly R, Emmady PD. Paraneoplastic Cerebellar Degeneration. [Updated 2023 Jul 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan​. Glickstein M, Strata P, Voogd J. Cerebellum: history. Neuroscience. 2009 Sep 1;162(3):549-59. doi: 10.1016/j.neuroscience.2009.02.054. Epub 2009 Mar 9.​ Greenlee JE. Treatment of paraneoplastic cerebellar degeneration. Curr Treat Options Neurol. 2013 Apr;15(2):185-200. ​Leigh J, Zee D. Neurology of Eye Movements. Oxford University Press; 5th edition (July 2 2015). ​Wahed LA, Cho TA. Imaging of Central Nervous System Autoimmune, Paraneoplastic, and Neuro-rheumatologic Disorders. Continuum (Minneap Minn). 2023 Feb 1;29(1):255-291.
Language eng
Format application/pdf
Type Text
Collection Neuro-Ophthalmology Virtual Education Library: NOVEL https://NOVEL.utah.edu
Publisher North American Neuro-Ophthalmology Society
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management Copyright 2024. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright
ARK ark:/87278/s6shatq1
Setname ehsl_novel_novel
ID 2456811
Reference URL https://collections.lib.utah.edu/ark:/87278/s6shatq1
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