There is one motor and two sensory pathways that must be mastered. Pain and temperature from the body travel together and vibration and proprioception travel in another pathway each reaching perception in the cortex. Voluntary motor control starts in the cerebral cortex and connects with a motor neuron in the spinal cord or brain stem. Each of these pathways has a different crossing point which is important. With these 3 pathways and your 12 cranial nerves you can localize many diseases.