| Publication Type |
Manuscript |
| School or College |
School of Medicine |
| Department |
Neurosurgery |
| Creator |
Couldwell, William T.; Gillespie, David L.; Jensen, Randy L. |
| Other Author |
Ragel, Brian T. |
| Title |
Identification of hypoxia-induced genes in a malignant glioma cell line (U-251) by cDNA microarray analysis |
| Date |
2007 |
| Description |
Overcoming the metabolic restrictions of hypoxia may allow the progression of lower-grade tumors to glioblastoma multiforme. Our findings of up-regulation of HIF-1α and its downstream targets VEGF, GLUT-1, and CAIX in higher-grade gliomas support this hypothesis. We compared the gene expression profiles of the U-251 malignant glioma cell line under normoxic and hypoxic conditions to discover future research targets. |
| Type |
Text |
| Publisher |
Springer |
| Volume |
30 |
| Issue |
3 |
| First Page |
181 |
| Last Page |
187 |
| Subject |
Glioblastoma multiforme; U-251; Hypoxia; Microarray analysis; Brain tumor; Depp; Astrocytoma |
| Subject LCSH |
Cerebral anoxia; Gliomas -- Genetic aspects; Brain -- Cancer |
| Language |
eng |
| Bibliographic Citation |
Ragel, B. T., Couldwell, W. T., Gillespie, D. L., & Jensen, R. L. (2007). Identification of hypoxia-induced genes in a malignant glioma cell line (U-251) by cDNA microarray analysis. Neurosurgical Review, 30(3), 181-7. |
| Rights Management |
(c) Springer (The original publication is available at www.springerlink.com) |
| Format Medium |
application/pdf |
| Format Extent |
211,558 bytes |
| Identifier |
ir-main,12644 |
| ARK |
ark:/87278/s6hx1wtc |
| Setname |
ir_uspace |
| ID |
703396 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6hx1wtc |
